Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain
poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22 …

Being a morning person is a behavioural indicator of a person's underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase …

In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting
cues, adjusting internal∼ 24 h rhythms to resonate with, and anticipate, external cycles of …

Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes∼
24 hr rhythms in many behavioral and physiological processes. This system is altered in …

The eukaryotic biological clock involves a negative transcription-translation feedback loop in
which clock genes regulate their own transcription and that of output genes of metabolic …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

The mammalian circadian clock involves a transcriptional feed back loop in which CLOCK
and BMAL1 activate the Period and Cryptochrome genes, which then feedback and repress …

Abstract BioGPS (http://biogps. org) is a centralized gene-annotation portal that enables
researchers to access distributed gene annotation resources. This article focuses on the …