Simple Summary Medulloblastoma is the most common pediatric brain tumor, comprising
one-third of all pediatric brain tumors, and originating in the posterior fossa of the brain. The …

Transcriptional deregulation, a cancer cell hallmark, is driven by epigenetic abnormalities in
the majority of brain tumors, including adult glioblastoma and pediatric brain tumors …

Sonic hedgehog (Shh) signaling plays a critical role in regulating cerebellum development
by maintaining the physiological proliferation of granule neuron precursors (GNPs), and its …

Background: Approximately 30% of children with medulloblastoma (MB) experience
recurrence, which is usually incurable. This study compared the overall survival (OS) of …

Medulloblastoma is the most common malignant brain tumor in children. Over the last few
decades, significant progress has been made in revealing the key molecular underpinnings …

Radiotherapy is one of the standard therapeutic regimens for medulloblastoma (MB). Tumor
cells utilize DNA damage repair (DDR) mechanisms to survive and develop resistance …

Background Conventional parameters show limited and unreliable correlations with
medulloblastoma prognosis. Aim To evaluate the factors influencing overall survival (OS) …

Pediatric brain tumor treatments have a high success rate, but survivors are at risk of
cognitive sequelae that impact long-term quality of life. We summarize recent clinical and …

Abstract Group 3 medulloblastoma (G3 MB) carries the worst prognosis of all MB subgroups.
MYC oncoprotein is elevated in G3 MB tumors; however, the mechanisms that support MYC …

Background Wingless-activated medulloblastoma (WNT MB) represents a well-
characterized molecular variant accounting for 10–15% of all MB and is associated with a …