Alternative splicing: the pledge, the turn, and the prestige: the key role of alternative splicing in human biological systems

LM Gallego-Paez, MC Bordone, AC Leote… - Human genetics, 2017 - Springer
Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome,
with the assistance of several regulators, resulting in the expression of different transcript …

RNA splicing regulators play critical roles in neurogenesis

E Fisher, J Feng - Wiley Interdisciplinary Reviews: RNA, 2022 - Wiley Online Library
Alternative RNA splicing increases transcript diversity in different cell types and under
varying conditions. It is executed with the help of RNA splicing regulators (RSRs), which are …

The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model

Y Li, J Xu, X Guo, Z Li, L Cao, S Liu, Y Guo, G Wang… - Genome biology, 2023 - Springer
Abstract Background The CRISPR-Cas13 system is an RNA-guided RNA-targeting system
and has been widely used in transcriptome engineering with potentially important clinical …

PICASSO allows ultra-multiplexed fluorescence imaging of spatially overlapping proteins without reference spectra measurements

J Seo, Y Sim, J Kim, H Kim, I Cho, H Nam… - Nature …, 2022 - nature.com
Ultra-multiplexed fluorescence imaging requires the use of spectrally overlapping
fluorophores to label proteins and then to unmix the images of the fluorophores. However …

Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function

S Hosseini, E Wilk, K Michaelsen-Preusse… - Journal of …, 2018 - Soc Neuroscience
Acute influenza infection has been reported to be associated with neurological symptoms.
However, the long-term consequences of an infection with neurotropic and non-neurotropic …

Neuronal activity drives IGF2 expression from pericytes to form long-term memory

K Pandey, B Bessières, SL Sheng, J Taranda, P Osten… - Neuron, 2023 - cell.com
Investigations of memory mechanisms have been, thus far, neuron centric, despite the brain
comprising diverse cell types. Using rats and mice, we assessed the cell-type-specific …

Brain-reactive autoantibodies in neuropsychiatric systemic lupus erythematosus

C Cocco, E Manca, G Corda, MM Angioni… - Frontiers in …, 2023 - frontiersin.org
Introduction The pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) is
widely unknown, and the role of autoantibodies is still undetermined. Methods To identify …

Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression

PS Chong, CH Poon, J Roy, KC Tsui, SY Lew… - Chinese Medicine, 2021 - Springer
Background Depression is a severe neuropsychiatric disorder that affects more than 264
million people worldwide. The efficacy of conventional antidepressants are barely adequate …

Frequency of spontaneous neurotransmission at individual boutons corresponds to the size of the readily releasable pool of vesicles

AJ Ralowicz, S Hokeness, MB Hoppa - Journal of Neuroscience, 2024 - Soc Neuroscience
Synapses maintain two forms of neurotransmitter release to support communication in the
brain. First, evoked neurotransmitter release is triggered by the invasion of an action …

Hypothermic protection in neocortex is topographic and laminar, seizure unmitigating, and partially rescues neurons depleted of RNA splicing protein Rbfox3/NeuN in …

CT Primiani, JK Lee, CE O'Brien, MW Chen, J Perin… - Cells, 2023 - mdpi.com
The effects of hypothermia on neonatal encephalopathy may vary topographically and
cytopathologically in the neocortex with manifestations potentially influenced by seizures …