Therapeutic peptides have revolutionized treatment for a number of human diseases. In
particular, the past two decades have witnessed rapid progress of stapled helical peptides in …

There are a wealth of proteins involved in disease that cannot be targeted by current
therapeutics because they are inside cells, inaccessible to most macromolecules, and lack …

Artificial intelligence (AI) has gained significant traction in the field of drug discovery, with
deep learning (DL) algorithms playing a crucial role in predicting protein–ligand binding …

Specific interaction between the postsynaptic density protein 95 (PSD95) and synapse-
associated protein 90/postsynaptic density 95–associated protein (SAPAP) is crucial for …

CDK9 (cyclin-dependent kinase 9) plays a significant role in numerous pathological
conditions, such as HIV-1 infection and cancer. The interaction between CDK9 and cyclin T1 …

Extracellular vesicles (EVs) have attracted an attention as important targets in the fields of
biology and medical science because they contain physiologically active molecules …

Stabilization of a peptide conformation via stapling strategy may be realized by the
reversible or more often irreversible connection of side chains being in mutually appropriate …

Stapled peptides are a promising class of molecules with potential as highly specific probes
of protein–protein interactions and as therapeutics. Hydrocarbon stapling affects the peptide …

The ability to modulate cellular responses with light is the essence of photopharmacology.
Photocontrollable peptides, capable of reversibly adopting either an active conformation or …

What is the essential requirement for the existence of living beings? In the early 19th
century, this question was approached in two different ways. The first approach proposed …