The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …

The health benefits of regular recreational physical activity are well known in reducing
secondary health consequences of a sedentary lifestyle in the general population. However …

Because of its high prevalence and implications for quality of life and possibly even disease
progression, depression has been intensively studied in multiple sclerosis (MS) over the …

Neuropsychiatric signs and symptoms occur frequently in individuals with multiple sclerosis
(MS), either as the initial presenting complaint prior to a definitive neurological diagnosis or …

Fatigue is a frequent and disabling symptom in patients with multiple sclerosis (MS), but it is
difficult to define and measure. Today, MS-related fatigue is not fully understood, and …

Multiple Sclerosis (MS) is one of the most common chronic diseases of the central nervous
system, and in New Zealand an estimated 4000 people are currently affected. This study …

Depressed patients show evidence of both proinflammatory changes and
neurophysiological abnormalities such as increased amygdala reactivity and volumetric …

Anxiety and depression are widely distributed symptoms among multiple sclerosis patients
and in the general population. We assessed the prevalence of anxiety and depression in the …

Gay M‐C, Vrignaud P, Garitte C, Meunier C. Predictors of depression in multiple sclerosis
patients. Acta Neurol Scand: 2010: 121: 161–170.© 2010 The Authors Journal compilation© …

Neuropsychiatric abnormalities are common in MS patients. No aspect of mentation is
spared. Advances in neuroimaging are increasing our understanding of the pathogenesis of …