Because of its ability to find complex patterns in high dimensional and heterogeneous data,
machine learning (ML) has emerged as a critical tool for making sense of the growing …

Messenger RNA based therapeutics have the potential to cause a big revolution in medicine
as they can facilitate personalized medicines and allow patients to produce their own …

Abstract Background Some circular RNAs (circRNAs) can be translated into functional
peptides by small open reading frames (ORFs) in a cap-independent manner. Internal …

Recent work has brought to light many different mechanisms of translation initiation that
function in cells in parallel to canonical cap‐dependent initiation. This has important …

Many conditions can benefit from RNA-based therapies, namely, those targeting internal
ribosome entry sites (IRESs) and their regulatory proteins, the IRES trans-acting factors …

Background Internal ribosome entry sites (IRES) are segments of mRNA found in
untranslated regions that can recruit the ribosome and initiate translation independently of …

It is now known that cap-independent translation initiation facilitated by internal ribosome
entry sites (IRESs) is vital in selective cellular protein synthesis under stress and different …

Viruses are obligate intracellular parasites that depend on the host's protein synthesis
machinery for translating their mRNAs. The viral mRNA (vRNA) competes with the host …

The internal ribosome entry site (IRES) is a cis-regulatory element that can initiate
translation in a cap-independent manner. It is often related to cellular processes and many …

Circular RNAs (circRNAs) have been found to have the ability to encode proteins through
internal ribosome entry sites (IRESs), which are essential RNA regulatory elements for cap …