Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Background and Aims Oxidative stress plays a key role in the development of metabolic
complications associated with obesity, including insulin resistance and the most common …

Background Perturbations in myocardial substrate utilization have been proposed to
contribute to the pathogenesis of cardiac dysfunction in diabetic subjects. The failing heart in …

Non-coding RNAs are pivotal for many cellular functions, such as splicing, gene regulation,
chromosome structure, and hormone-like activity. Here, we will report about the biology and …

Diabetic nephropathy (DN) is the leading cause of end‐stage kidney disease. TGF‐
β1/Smad3 signalling plays a major pathological role in DN; however, the contribution of …

Background Metabolic remodeling in cardiomyocytes is deeply associated with the
pathogenesis of heart failure (HF). Glutaminolysis is an anaplerotic pathway that …

Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It is unrelated
to hypertension and coronary artery disease and can lead to heart insufficiency, heart failure …

Wound healing in diabetic skin is impaired by excessive activation of matrix
metalloproteinase-9 (MMP-9). MMP-9 transcription is activated by Ten-eleven translocation …

Aims: α-Ketoglutarate (AKG) is an intermediate of the tricarboxylic acid cycle and a key hub
linking amino acid metabolism and glucose oxidation. Previous studies have shown that …