Pathogenesis and management of postprandial hyperglycemia: role of incretin-based therapies

J Gerich - International journal of general medicine, 2013 - Taylor & Francis
Postprandial plasma glucose concentrations are an important contributor to glycemic
control. There is evidence suggesting that postprandial hyperglycemia may be an …

Randomized, double‐blind, placebo‐controlled trial of the once‐daily GLP‐1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently …

Y Seino, KW Min, E Niemoeller… - Diabetes, Obesity …, 2012 - Wiley Online Library
Aims To assess the efficacy and safety of once‐daily lixisenatide versus placebo in Asian
patients with type 2 diabetes insufficiently controlled on basal insulin±sulfonylurea. Methods …

Mechanisms and clinical efficacy of lixisenatide for the management of type 2 diabetes

M Horowitz, CK Rayner, KL Jones - Advances in therapy, 2013 - Springer
Abstract Introduction “Incretin-based” therapies, such as the glucagon-like peptide-1 (GLP-1)
receptor agonists, represent a major advance in type 2 diabetes mellitus (T2DM) treatment …

Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin

C Kapitza, T Forst, HV Coester… - Diabetes, Obesity …, 2013 - Wiley Online Library
Aim Assess the pharmacodynamics of lixisenatide once daily (QD) versus liraglutide QD in
type 2 diabetes insufficiently controlled on metformin. Methods In this 28‐day, randomized …

Efficacy and safety of lixisenatide once-daily morning or evening injections in type 2 diabetes inadequately controlled on metformin (GetGoal-M)

B Ahrén, A Leguizamo Dimas, P Miossec… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE To examine the efficacy and safety of lixisenatide (20 μg once daily,
administered before the morning or evening meal) as add-on therapy in patients with type 2 …

[HTML][HTML] Effects of lixisenatide once daily on gastric emptying in type 2 diabetes—relationship to postprandial glycemia

M Lorenz, C Pfeiffer, A Steinsträßer, RHA Becker… - Regulatory peptides, 2013 - Elsevier
Objectives To determine the effects of lixisenatide, a new once-daily (QD) glucagon-like
peptide-1 receptor agonist, on postprandial glucose (PPG) and gastric emptying, and the …

Efficacy and safety of lixisenatide once daily versus placebo in type 2 diabetes insufficiently controlled on pioglitazone (GetGoal‐P)

M Pinget, R Goldenberg, E Niemoeller… - Diabetes, Obesity …, 2013 - Wiley Online Library
Aims To compare the efficacy and safety of once‐daily prandial lixisenatide with placebo in
type 2 diabetes mellitus (T2DM) insufficiently controlled by pioglitazone±metformin. Methods …

Lixisenatide treatment improves glycaemic control in Asian patients with type 2 diabetes mellitus inadequately controlled on metformin with or without sulfonylurea: a …

C Yu Pan, P Han, X Liu, S Yan, P Feng… - Diabetes/metabolism …, 2014 - Wiley Online Library
Background This study assessed the efficacy and safety of the once‐daily glucagon‐like
peptide‐1 receptor agonist, lixisenatide, in Asian patients with type 2 diabetes mellitus …

Efficacy and safety of lixisenatide in elderly (≥ 65 years old) and very elderly (≥ 75 years old) patients with type 2 diabetes: an analysis from the GetGoal phase III …

D Raccah, P Miossec, V Esposito… - Diabetes/Metabolism …, 2015 - Wiley Online Library
Background The objective of this article is to evaluate the pharmacokinetics, efficacy and
safety of lixisenatide (subcutaneous injection) in elderly (≥ 65 years old) and very elderly …

[HTML][HTML] Effects of the GLP-1 receptor agonist lixisenatide on postprandial glucose and gastric emptying–preclinical evidence

U Werner - Journal of Diabetes and its Complications, 2014 - Elsevier
In addition to promoting glucose homeostasis, glucagon-like peptide 1 (GLP-1) has a
number of extra-pancreatic effects that regulate appetite and body weight. GLP-1 delays …