The incidence and mortality of hepatocellular carcinoma (HCC) are on a rise in the Western
countries including US, attributed mostly to late detection. Sorafenib has been the first-line …

Adiponectin is an adipocyte-secreted adipokine with pleiotropic actions. Clinical evidence
has shown that serum adiponectin levels are increased and that adiponectin can protect …

Basal-like breast cancers (BLBC) are poorly differentiated and display aggressive clinical
behavior. These tumors become resistant to cytotoxic agents, and tumor relapse has been …

Abstract Specification and early patterning of the vertebrate heart are dependent on both
canonical and noncanonical wingless (Wnt) signal pathways. However, the impact of each …

Background Acquisition of drug-resistance in cancer has led to treatment failure, however,
their mechanisms have not been clarified yet. Recent observations indicated that aberrant …

Gastrin is a gastrointestinal peptide hormone, secreted by the gastric G cells and can exist
as a fully processed amidated form (G17) or as unprocessed forms. All forms of gastrin …

Advanced hepatocellular carcinoma (HCC) is a lethal disease, with limited therapeutic
options. Mixed Lineage Kinase 3 (MLK3) is a key regulator of liver diseases, although its …

Acute myeloid leukemia is a heterogeneous disease with varying genetic and molecular
pathologies. Non-steroidal anti-inflammatory drugs (NSAIDs) have been proven to possess …

Tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) is an endogenous
secreted peptide and, in preclinical studies, preferentially induces apoptosis in tumor cells …

Aims: Reactive oxygen species (ROS) play a vital role in conveying the cytotoxicity and
resistance of most chemotherapy drugs. Therefore, gaining a comprehensive understanding …