Metal coordination complexes as therapeutic agents for ischemia-reperfusion injury
NP Bigham, JJ Wilson - Journal of the American Chemical Society, 2023 - ACS Publications
Ischemia-reperfusion injury (IRI), which describes the cell damage and death that occurs
after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor …
after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor …
Mn porphyrin-based redox-active drugs: differential effects as cancer therapeutics and protectors of normal tissue against oxidative injury
I Batinic-Haberle, A Tovmasyan… - Antioxidants & Redox …, 2018 - liebertpub.com
Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …
Redox paradox: a novel approach to therapeutics-resistant cancer
L Chaiswing, WH St. Clair… - Antioxidants & redox …, 2018 - liebertpub.com
Significance: Cancer cells that are resistant to radiation and chemotherapy are a major
problem limiting the success of cancer therapy. Aggressive cancer cells depend on elevated …
problem limiting the success of cancer therapy. Aggressive cancer cells depend on elevated …
Radiation-mediated tumor growth inhibition is significantly enhanced with redox-active compounds that cycle with ascorbate
A Tovmasyan, JC Bueno-Janice… - Antioxidants & redox …, 2018 - liebertpub.com
Aims: We aim here to demonstrate that radiation (RT) enhances tumor sensitization by only
those Mn complexes that are redox active and cycle with ascorbate (Asc), thereby producing …
those Mn complexes that are redox active and cycle with ascorbate (Asc), thereby producing …
Hematopoietic Stem Cells: Normal Versus Malignant
D Carroll, DK St. Clair - Antioxidants & redox signaling, 2018 - liebertpub.com
Significance: The long-term hematopoietic stem cell (LT-HSC) demonstrates characteristics
of self-renewal and the ability to manage expansion of the hematopoietic compartment while …
of self-renewal and the ability to manage expansion of the hematopoietic compartment while …
Targeting the Cellular Redox Environment: A Novel Approach for the Treatment of Hematopoietic Neoplasms
DW Carroll - 2018 - uknowledge.uky.edu
Hematopoietic stem cells (HSCs) that function to maintain the hematopoietic compartment
through self-renewal and differentiation capacities, as well as their downstream progeny, are …
through self-renewal and differentiation capacities, as well as their downstream progeny, are …