Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Aims The objective of this umbrella review and meta‐analysis was to evaluate the effect of
diabetes on risk of dementia, as well as the mitigating effect of antidiabetic treatments …

Several epidemiological studies have clearly identified diabetes mellitus (DM) as a major
risk factor for cognitive dysfunction, and it is going to be a major public health issue in the …

Importance Dementia affects 10% of those 65 years or older and 35% of those 90 years or
older, often with profound cognitive, behavioral, and functional consequences. As the baby …

Metformin, a widely prescribed medication for type 2 diabetes, has garnered increasing
attention for its potential neuroprotective properties due to the growing demand for …

Introduction Metformin has shown good efficacy in the management of antipsychotic-
induced metabolic syndrome (MetS) in patients with schizophrenia or schizoaffective …

Dementia dramatically affects the activities of daily living and quality of life; thus, many
therapeutic approaches for overcoming dementia have been developed. However, an …

From an epidemiological and pathophysiological point of view, Alzheimer's disease (AD)
and type 2 diabetes (T2DM) should be considered'sister'diseases. T2DM significantly …

Alzheimer's disease (AD) constitutes a major public-health issue of our time. Regrettably,
despite our considerable understanding of the pathophysiological aspects of this disease …

Neuroinflammation is a pathological hallmark of Alzheimer's disease (AD), characterized by
the stimulation of resident immune cells of the brain and the penetration of peripheral …