Anti-cancer chalcones: Structural and molecular target perspectives

DK Mahapatra, SK Bharti, V Asati - European journal of medicinal chemistry, 2015 - Elsevier
Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

Naturally occurring chalcones and their biological activities

Z Rozmer, P Perjési - Phytochemistry reviews, 2016 - Springer
The aim of this review is to summarize the various naturally occurring chalcone compounds
which have been isolated from different plants. Chalcones considered as obligate …

African natural products with potential antioxidants and hepatoprotectives properties: a review

B Lawal, OK Shittu, FI Oibiokpa, EB Berinyuy… - Clinical …, 2017 - Springer
Free radicals are highly reactive molecules generated during oxidation reactions which in
turn initiate chain reactions resulting to cellular damage. There is substantial evidence …

Natural dimers of coumarin, chalcones, and resveratrol and the link between structure and pharmacology

JC Menezes, MF Diederich - European Journal of Medicinal Chemistry, 2019 - Elsevier
Natural products like coumarins, chalcones, and resveratrol have inherent biological activity
in several models of diseases; therefore, their natural dimeric forms are highlighted in this …

Anticancer activity of Nigerian medicinal plants: a review

FO Ohiagu, PC Chikezie, CM Chikezie… - Future Journal of …, 2021 - Springer
Background Cancer is currently the leading cause of death globally and the number of
deaths from cancer is on the rise daily. Medicinal plants have been in continuous use over …

Binding studies of lophirone B with bovine serum albumin (BSA): Combination of spectroscopic and molecular docking techniques

OA Chaves, VA da Silva, CMR Sant'Anna… - Journal of Molecular …, 2017 - Elsevier
The interaction between the transport protein bovine serum albumin (BSA) and the natural
product lophirone B, was investigated by spectroscopic techniques combined with a …

Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells

V Kuete, FW Fokou, O Karaosmanoğlu… - … and alternative medicine, 2017 - Springer
Background Cancer still constitutes one of the major health concerns globally, causing
serious threats on patients, their families, and the healthcare system. Methods In this study …

[1,2,4] Triazolo [3,4-a]isoquinoline chalcone derivative exhibits anticancer activity via induction of oxidative stress, DNA damage, and apoptosis in Ehrlich solid …

AA WalyEldeen, HM El-Shorbagy… - Naunyn-Schmiedeberg's …, 2022 - Springer
Despite the advances made in cancer therapeutics, their adverse effects remain a major
concern, putting safer therapeutic options in high demand. Since chalcones, a group of …

Bio-medical potential of chalcone derivatives and their metal complexes as antidiabetic agents: A review

R Kaushal, M Kaur - Journal of Coordination Chemistry, 2021 - Taylor & Francis
In nature, chalcones are extensively available in edible plants and as starting components of
flavonoids. Based on the presence of reactive bi-electrophilic group and the keto-vinyl …

[HTML][HTML] Effects of long-term Ailanthus altissima extract supplementation on fear, cognition and brain antioxidant levels

HMA Rahman, S Javaid, W Ashraf, MF Rasool… - Saudi Pharmaceutical …, 2023 - Elsevier
Introduction Ailanthus altissima is an indigenous plant known for various remedial
properties. The present study aimed to evaluate the neuroprotective potential of methanolic …