Cell death and immunity in cancer: from danger signals to mimicry of pathogen defense responses

AD Garg, P Agostinis - Immunological reviews, 2017 - Wiley Online Library
The immunogenicity of cancer cells is an emerging determinant of anti‐cancer
immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell‐based …

Interleukin-1 as innate mediator of T cell immunity

B Van Den Eeckhout, J Tavernier, S Gerlo - Frontiers in immunology, 2021 - frontiersin.org
The three-signal paradigm tries to capture how the innate immune system instructs adaptive
immune responses in three well-defined actions:(1) presentation of antigenic peptides in the …

[HTML][HTML] Immune checkpoint inhibitors in EGFR-mutated NSCLC: dusk or dawn?

M Qiao, T Jiang, X Liu, S Mao, F Zhou, X Li… - Journal of Thoracic …, 2021 - Elsevier
Although immune checkpoint inhibitors (ICIs) that target programmed cell death protein-
1/programmed cell death ligand-1 axis have significantly shifted the treatment paradigm in …

Integrating next-generation dendritic cell vaccines into the current cancer immunotherapy landscape

AD Garg, PG Coulie, BJ Van den Eynde… - Trends in …, 2017 - cell.com
Cancer immunotherapy is experiencing a renaissance spearheaded by immune checkpoint
inhibitors (ICIs). This has spurred interest in 'upgrading'existing immunotherapies that …

Therapeutic applications of nanobiotechnology

Y Dutt, RP Pandey, M Dutt, A Gupta, A Vibhuti… - Journal of …, 2023 - Springer
Nanobiotechnology, as a novel and more specialized branch of science, has provided a
number of nanostructures such as nanoparticles, by utilizing the methods, techniques, and …

Tumor-derived exosomes: the next generation of promising cell-free vaccines in cancer immunotherapy

M Naseri, M Bozorgmehr, M Zöller… - …, 2020 - Taylor & Francis
Identification of immunogenic tumor antigens that are efficiently processed and delivered by
dendritic cells to prime the immune system and to induce an appropriate immune response …

Extracellular vesicles as antigen carriers for novel vaccination avenues

M Mehanny, CM Lehr, G Fuhrmann - Advanced drug delivery reviews, 2021 - Elsevier
Antigen delivery has always been a challenge in scientific practice of vaccine formulation.
Yet, mammalian extracellular vesicles (EVs) or bacterial membrane vesicles (MVs) provide …

Current State of Dendritic Cell-Based Immunotherapy: Opportunities for in vitro Antigen Loading of Different DC Subsets?

A Huber, F Dammeijer, JGJV Aerts… - Frontiers in …, 2018 - frontiersin.org
Dendritic cell (DC) based cancer immunotherapy aims at the activation of the immune
system, and in particular tumor-specific cytotoxic T lymphocytes (CTLs) to eradicate the …

Antitumor dendritic cell–based vaccines: lessons from 20 years of clinical trials and future perspectives

J Constantino, C Gomes, A Falcão, MT Cruz… - Translational …, 2016 - Elsevier
Dendritic cells (DCs) are versatile elements of the immune system and are best known for
their unparalleled ability to initiate and modulate adaptive immune responses. During the …

A bird's eye view on the role of dendritic cells in SARS‐CoV‐2 infection: Perspectives for immune‐based vaccines

D Galati, S Zanotta, L Capitelli, M Bocchino - Allergy, 2022 - Wiley Online Library
Abstract Coronavirus disease‐19 (COVID‐19) is a complex disorder caused by the
pandemic diffusion of a novel coronavirus named SARS‐CoV‐2. Clinical manifestations …