Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …
cause of numerous health complications and increased mortality. Being a complex and …
Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
DM Meyer, MI Jesson, X Li, MM Elrick… - Journal of …, 2010 - Springer
Abstract Background The Janus kinase (JAK) family of tyrosine kinases includes JAK1,
JAK2, JAK3 and TYK2, and is required for signaling through Type I and Type II cytokine …
JAK2, JAK3 and TYK2, and is required for signaling through Type I and Type II cytokine …
Recent advances in understanding leptin signaling and leptin resistance
The brain controls energy homeostasis and body weight by integrating various metabolic
signals. Leptin, an adipose-derived hormone, conveys critical information about peripheral …
signals. Leptin, an adipose-derived hormone, conveys critical information about peripheral …
PKD1 induces p21waf1 and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2
Autosomal dominant polycystic kidney disease is characterized by cyst formation in the
kidney and other organs and results from mutations of PKD1 or PKD2. Previous studies …
kidney and other organs and results from mutations of PKD1 or PKD2. Previous studies …
Signaling pathways activated by the growth hormone receptor
J Herrington, C Carter-Su - Trends in Endocrinology & Metabolism, 2001 - cell.com
In recent years, significant progress has been made in elucidating the signaling pathways
activated by the growth hormone (GH) receptor. An initiating event is probably the activation …
activated by the growth hormone (GH) receptor. An initiating event is probably the activation …
The role of STAT proteins in growth hormone signaling
J Herrington, LS Smit, J Schwartz, C Carter-Su - Oncogene, 2000 - nature.com
Growth hormone (GH) has long been known to be the body's primary regulator of body
growth and a regulator of metabolism, yet the mechanisms by which GH regulates the …
growth and a regulator of metabolism, yet the mechanisms by which GH regulates the …
Human SH2B1 mutations are associated with maladaptive behaviors and obesity
ME Doche, EG Bochukova, HW Su… - The Journal of …, 2012 - Am Soc Clin Investig
Src homology 2 B adapter protein 1 (SH2B1) modulates signaling by a variety of ligands that
bind to receptor tyrosine kinases or JAK-associated cytokine receptors, including leptin …
bind to receptor tyrosine kinases or JAK-associated cytokine receptors, including leptin …
Growth hormone (GH), GH receptor, and signal transduction
JJ Kopchick, JM Andry - Molecular genetics and metabolism, 2000 - Elsevier
Clinical observations of the function of the pituitary gland are credited to Pierre Marie, who,
in 1886, noted the large size of the gland in an acromegalic patient. In the early 1900s, the …
in 1886, noted the large size of the gland in an acromegalic patient. In the early 1900s, the …
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
P Saharinen, M Vihinen… - Molecular biology of the …, 2003 - Am Soc Cell Biol
Jak tyrosine kinases have a unique domain structure containing a kinase domain (JH1)
adjacent to a catalytically inactive pseudokinase domain (JH2). JH2 is crucial for inhibition of …
adjacent to a catalytically inactive pseudokinase domain (JH2). JH2 is crucial for inhibition of …