Factors affecting antimicrobial resistance in Streptococcus pneumoniae following vaccination introduction

ER Watkins, A Kalizang'Oma, A Gori, S Gupta… - Trends in …, 2022 - cell.com
Streptococcus pneumoniae is a major cause of pneumonia, meningitis, and septicaemia
worldwide. Pneumococcal antimicrobial resistance (AMR) has been highlighted by the WHO …

The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi

U Obolski, TD Swarthout, A Kalizang'oma… - Nature …, 2023 - nature.com
Streptococcus pneumoniae causes substantial mortality among children under 5-years-old
worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing …

Clinical Relevance and Molecular Pathogenesis of the Emerging Serotypes 22F and 33F of Streptococcus pneumoniae in Spain

J Sempere, S De Miguel… - Frontiers in …, 2020 - frontiersin.org
Streptococcus pneumoniae is the main bacterial cause of respiratory infections in children
and the elderly worldwide. Serotype replacement is a frequent phenomenon after the …

Streptococcus pneumoniae serotypes that frequently colonise the human nasopharynx are common recipients of penicillin-binding protein gene fragments from …

A Kalizang'oma, C Chaguza, A Gori… - Microbial …, 2021 - microbiologyresearch.org
Streptococcus pneumoniae is an important global pathogen that causes bacterial
pneumonia, sepsis and meningitis. Beta-lactam antibiotics are the first-line treatment for …

Population genomics of pneumococcal carriage in South Africa following the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) immunization

N Javaid, C Olwagen, S Nzenze… - Microbial …, 2022 - microbiologyresearch.org
Streptococcus pneumoniae is a major human pathogen responsible for over 317000 deaths
in children< 5 years of age with the burden of the disease being highest in low-and middle …

Genomic surveillance of invasive Streptococcus pneumoniae isolates in the period pre-PCV10 and post-PCV10 introduction in Brazil

SCG Almeida, SW Lo, PA Hawkins… - Microbial …, 2021 - microbiologyresearch.org
In 2010, Brazil introduced the 10-valent pneumococcal conjugate vaccine (PCV10) into the
national children's immunization programme. This study describes the genetic …

Optimal age targeting for pneumococcal vaccination in older adults; a modelling study

D Thindwa, S Clifford, J Kleynhans… - Nature …, 2023 - nature.com
Invasive pneumococcal disease (IPD) risk increases with age for older adults whereas the
population size benefiting from pneumococcal vaccines and robustness of immunogenic …

Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent …

A Kalizang'oma, TD Swarthout… - The Journal of …, 2024 - academic.oup.com
Background Streptococcus pneumoniae serotype 3 remains a problem globally. Malawi
introduced 13-valent pneumococcal conjugate vaccine (PCV13) in 2011, but there has been …

Natural Carriage of Streptococcus pneumoniae Is Associated With Increased Experimental Pneumococcal Carriage but Reduced Conjugate Vaccine Efficacy in a …

B Galafa, T Chikaonda, E Kudowa… - The Journal of …, 2024 - academic.oup.com
Abstract Background In Malawi, the national 13-valent pneumococcal conjugate vaccine
(PCV13) demonstrated less herd immunity than in the United States, likely due to higher …

The metabolic, virulence and antimicrobial resistance profiles of colonizing Streptococcus pneumoniae shift after pneumococcal vaccine introduction in urban Malawi

A Gori, U Obolski, TD Swarthout, J Lourenço… - medRxiv, 2021 - medrxiv.org
Streptococcus pneumoniae accounts for at least 300,000 deaths from pneumonia,
septicaemia and meningitis among children under 5-years-old worldwide. Protein …