DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

Gastrointestinal stromal tumors (GIST) harbor driver mutations of signal transduction kinases
such as KIT, or, alternatively, manifest loss-of-function defects in the mitochondrial succinate …

Limited information is available regarding epigenomic events mediating initiation and
progression of tobacco-induced lung cancers. In this study, we established an in vitro system …

Tumours lacking argininosuccinate synthetase-1 (ASS1) are auxotrophic for arginine and
sensitive to amino-acid deprivation. Here, we investigated the role of ASS1 as a biomarker …

Background Mediastinal gray zone lymphoma is a newly recognized entity with transitional
morphological and immunophenotypic features between the nodular sclerosis subtype of …

High throughput genomic assays empower us to study the entire human genome in short
time with reasonable cost. Formalin fixed‐paraffin‐embedded (FFPE) tissue processing …

Background Alterations in the DNA methylation pattern are a hallmark of leukemias and
lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have …

The molecular pathogenesis of benign and malignant adrenocortical tumors (ACT) is
incompletely clarified. The role of DNA methylation in adrenocortical tumorigenesis has not …

Microarray technologies provide high-resolution maps of chromosome imbalances and
epigenomic aberrations in the cancer cell genome. Such assays are often sensitive to …