The 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-
known heterocycles, being a common and essential feature of a variety of natural products …

Abstract The ESKAPE (Escherichia coli/E. coli, Staphylococcus aureus/S. aureus, Klebsiella
pneumonia/K. pneumoniae, Acinetobacter Baumannii/A. baumannii, Pseudomonas …

Bacterial infection is amongst the most common diseases in community and hospital
settings. Fluoroquinolones, exerting the antibacterial activity through binding to type II …

The DNA topoisomerase enzymes are widely distributed throughout all spheres of life and
are necessary for cell function. Numerous antibacterial and cancer chemotherapeutic drugs …

Thiazolidinones and phenylaminopyrimidines are known as anticancer agents. Imatinib is
the pioneer phenylaminopyrimidine derivative kinase inhibitor, which is used for the …

Cancer is a very risky life-threatening disease having most formidable afflictions in the world.
Several anticancer agents are commercially accessible, however, the emergence of …

Amongst the fluoroquinolone antibacterials, the 7-piperazinyl containing chemotypes such
as norfloxacin, enoxacin, ciprofloxacin, pefloxacin, lomefloxacin, enrofloxacin, ofloxacin …

Among all modern antibiotics, fluoroquinolones are well known for their broad spectrums of
activity and efficiency toward microorganisms and viruses. However, antibiotic resistance is …

Novel substituted fluoroquinolone derivatives, compounds 6–20 were designed,
synthesized, and evaluated for antituberculosis and antibacterial activity. Antibacterial …

Background: This review summarizes data on heterocyclic systems with thiadiazole and
thiazole fragments in molecules as promising antimicrobial agents. Introduction: Thiadiazole …