Behçet's disease: new insights into pathophysiology, clinical features and treatment options

A Greco, A De Virgilio, M Ralli, A Ciofalo, P Mancini… - Autoimmunity …, 2018 - Elsevier
Behçet's disease (BD) is a rare systemic vasculitis characterized by oral aphthous ulcers,
genital ulcers, ocular lesions and other systemic manifestations. BD occurs most frequently …

Immunopathogenesis of Behcet's disease

B Tong, X Liu, J Xiao, G Su - Frontiers in immunology, 2019 - frontiersin.org
Behcet's disease (BD) is a chronic systemic inflammatory vasculitis of unknown etiology
characterized by recurrent episodes of oral aphthous ulcers, genital ulcers, skin lesions …

Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis

Z Zhong, G Su, A Kijlstra, P Yang - Progress in retinal and eye research, 2021 - Elsevier
Uveitis is a group of diseases characterized by intraocular inflammation, of which some are
driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada …

[HTML][HTML] Immunopathogenesis of Behçet's disease and treatment modalities

TB Van der Houwen, PM van Hagen… - Seminars in Arthritis and …, 2022 - Elsevier
Introduction Behçet's disease (BD) is an auto-inflammatory disease, primarily characterized
by recurrent painful mucocutaneous ulcerations. Methods A literature search was performed …

Eubacterium rectale Attenuates HSV-1 Induced Systemic Inflammation in Mice by Inhibiting CD83

SMS Islam, HM Ryu, HM Sayeed, HO Byun… - Frontiers in …, 2021 - frontiersin.org
The purpose of this study was to determine whether administration of the microorganism
Eubacterium rectale (E. rectale) could regulate dendritic cell (DC) activation and systemic …

The Th17 pathway in vascular inflammation: culprit or consort?

M Robert, P Miossec, A Hot - Frontiers in Immunology, 2022 - frontiersin.org
The involvement of IL-17A in autoimmune and inflammatory diseases has prompted the
development of therapeutic strategies to block the Th17 pathway. Promising results came …

Interleukin‐35 regulates the balance of Th17 and Treg responses during the pathogenesis of connective tissue diseases

D Wang, L Lei - International journal of rheumatic diseases, 2021 - Wiley Online Library
Abstract Interleukin (IL)‐35 belongs to the IL‐12 cytokine family and is a heterodimer of the
p35 and Epstein‐Barr virus‐induced gene 3 (EBI3) subunits. Functionally, IL‐35 can …

Behçet disease: from pathogenesis to novel therapeutic options

J Rodríguez-Carrio, V Nucera, IF Masala… - Pharmacological …, 2021 - Elsevier
Behçet disease (BD) is a complex, multi-systemic inflammatory condition mainly hallmarked
by oral and genital ulcers which can also affect the vessels, gastrointestinal tract, central …

CD4+ T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease

YH Chen, S Lightman, VL Calder - International Journal of Molecular …, 2021 - mdpi.com
Non-infectious uveitis (NIU) is a potentially sight-threatening disease. Effector CD4+ T cells,
especially interferon-γ-(IFNγ) producing Th1 cells and interleukin-17-(IL-17) producing Th17 …

IL-35: a new immunomodulator in autoimmune rheumatic diseases

LI Sakkas, A Mavropoulos, C Perricone… - Immunologic …, 2018 - Springer
IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35
belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35. These cytokines …