The kallikrein–kinin system and oxidative stress

Y Kayashima, O Smithies, M Kakoki - Current opinion in …, 2012 - journals.lww.com
Accumulating evidence has highlighted the importance of the KKS as a protective system
against oxidative stress and organ damage in the heart and kidney. The activation of the …

[HTML][HTML] The kallikrein–kinin system in diabetic nephropathy

H Tomita, RB Sanford, O Smithies, M Kakoki - Kidney international, 2012 - Elsevier
Diabetic nephropathy is the major cause of end-stage renal disease worldwide. Although
the renin–angiotensin system has been implicated in the pathogenesis of diabetic …

Angiotensin‐converting‐enzyme insertion/deletion polymorphism, ACE activity, and COVID‐19: A rather controversial hypothesis. A case‐control study

A Papadopoulou, PC Fragkou… - Journal of Medical …, 2022 - Wiley Online Library
Accumulating data has shown a contribution of the renin‐angiotensin system in COVID‐19
pathogenesis. The role of angiotensin‐converting enzyme (ACE) insertion (I)/deletion (D) …

The angiotensin converting enzyme insertion/deletion polymorphism alters the response of muscle energy supply lines to exercise

D Vaughan, FA Huber-Abel, F Graber… - European journal of …, 2013 - Springer
The presence of a silencing sequence (the I-allele) in the gene for the upstream regulator of
blood flow, angiotensin I-converting enzyme (ACE), is associated with superior endurance …

Genomics in rugby union: A review and future prospects

SM Heffernan, LP Kilduff, SH Day… - European journal of …, 2015 - Taylor & Francis
This article introduces some aspects of sports genomics in a rugby union context, considers
the rugby-specific genetic data in the published literature and outlines the next research …

Previous experience, aerobic capacity and body composition are the best predictors for Olympic distance triathlon performance: Predictors in amateur triathlon

PJ Puccinelli, GHO Lima, JB Pesquero, CAB de Lira… - Physiology & …, 2020 - Elsevier
Objective: Present study examines predictors of the overall race time and disciplines in the
Olympic distance triathlon. Methods: Thirty-nine male and six female triathletes were …

ACE I/D polymorphism is a risk factor for the clinical severity of COVID-19 in Brazilian male patients

SS Almeida, MF Gregnani, IMG da Costa… - Molecular Biology …, 2024 - Springer
Background The renin-angiotensin system is potentially involved in the pathogen-host
interaction in the disease caused by SARS-CoV-2, since the angiotensin-converting enzyme …

Behavioural effects of the ACE insertion/deletion polymorphism in Alzheimer's disease depend upon stratification according to APOE-ϵ4 carrier status

FF Oliveira, SS de Almeida, MC Smith… - Cognitive …, 2021 - Taylor & Francis
Introduction: The inherited risk of late-onset Alzheimer's disease (AD) is genetically
determined. We aimed to examine associations of genetic variants of APOE and ACE with …

Functional regulation of Alu element of human angiotensin-converting enzyme gene in neuron cells

SJ Wu, TJ Hsieh, MC Kuo, ML Tsai, KL Tsai… - Neurobiology of …, 2013 - Elsevier
The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) genotype and its protein
activity have been widely implicated to be associated with Alzheimer's disease (AD) …

The angiotensin-I-converting enzyme insertion/deletion in polymorphic element codes for an AluYa5 RNA that downregulates gene expression

FFP Mafra, PP Gattai, MM Macedo, MA Mori… - The …, 2018 - nature.com
Angiotensin-I-converting enzyme (ACE) is involved in the synthesis and degradation of
important bioactive peptides. The ACE gene has a 287-bp insertion/deletion polymorphism …