Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

In the past decade, significant progress has been made in complex disease research across
multiple omics layers from genome, transcriptome and proteome to metabolome. There is an …

Epigenetics describes mechanisms which control gene expression and cellular processes
without changing the DNA sequence. The main mechanisms in epigenetics are DNA …

Testis development from an indifferent gonad is a critical step in embryogenesis. A hallmark
of testis differentiation is sex-specific vascularization that occurs as endothelial cells migrate …

Osteoporosis, characterised by low bone mass, poor bone structure, and an increased risk
of fracture, is a major public health problem. There is increasing evidence that the influence …

Poor intrauterine and childhood growth has been linked with the risk of osteoporosis in later
life, a relationship that may in part be mediated through altered epigenetic regulation of …

Polyunsaturated fatty acids (PUFAs) are a set of important nutrients that mainly include
arachidonic acid (ARA4), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and α …

Pug dogs with thoracolumbar myelopathy (PDM) present with a specific clinical phenotype
that includes progressive pelvic limb ataxia and paresis, commonly accompanied by …

Multiple profiling studies have identified a number of non-coding RNAs associated with the
pathogenesis of human diseases. However, the exact regulatory mechanisms and functions …

Genetic alterations are major contributing factors in the development of osteoporosis.
Osteoblasts and adipocytes share a common origin, mesenchymal stem cells (MSCs), and …