NPM1-mutated acute myeloid leukemia: from bench to bedside
The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations …
Hematopoietic stem cells and the immune system in development and aging
D Shevyrev, V Tereshchenko, TN Berezina… - International Journal of …, 2023 - mdpi.com
Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …
whole variety of cells of the immune system. Developing in the early embryo, passing …
Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML
Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation of poorly
differentiated myeloid cells, with a heterogenous mutational landscape. Mutations in IDH1 …
differentiated myeloid cells, with a heterogenous mutational landscape. Mutations in IDH1 …
Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network
YK Xia, YR Zeng, ML Zhang, P Liu, F Liu… - Protein & …, 2021 - academic.oup.com
Additional sex combs-like 1 (ASXL1) interacts with BRCA1-associated protein 1 (BAP1)
deubiquitinase to oppose the polycomb repressive complex 1 (PRC1)-mediated histone …
deubiquitinase to oppose the polycomb repressive complex 1 (PRC1)-mediated histone …
Integrated N- and O-Glycomics of Acute Myeloid Leukemia (AML) Cell Lines
Acute myeloid leukemia (AML) is characterized by a dysregulated expansion of poorly
differentiated myeloid cells. Although patients are usually treated effectively by …
differentiated myeloid cells. Although patients are usually treated effectively by …
Prognostic impact of FLT3‐ITD mutation on NPM1+ acute myeloid leukaemia patients and related molecular mechanisms
X Pan, Y Chang, G Ruan, F Wei, H Jiang… - British Journal of …, 2023 - Wiley Online Library
The prognosis of acute myeloid leukaemia (AML) patients carrying NPM1 mutations is
significantly worse when accompanied by FLT3‐ITD mutations. However, accurate …
significantly worse when accompanied by FLT3‐ITD mutations. However, accurate …
Functions of the native NPM1 protein and its leukemic mutant
The nucleophosmin (NPM1) gene encodes for the most abundant nucleolar protein. Thanks
to its property to act as histone chaperone and to shuttle between the nucleus and …
to its property to act as histone chaperone and to shuttle between the nucleus and …
ARPIR: automatic RNA-Seq pipelines with interactive report
G Spinozzi, V Tini, A Adorni, B Falini, MP Martelli - BMC bioinformatics, 2020 - Springer
Background RNA-Seq is an increasing used methodology to study either coding and non-
coding RNA expression. There are many software tools available for each phase of the RNA …
coding RNA expression. There are many software tools available for each phase of the RNA …
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice
P Sportoletti, D Sorcini, AG Guzman, JM Reyes… - Leukemia, 2021 - nature.com
Recurrent loss-of-function mutations of BCL6 co-repressor (BCOR) gene are found in about
4% of AML patients with normal karyotype and are associated with DNMT3a mutations and …
4% of AML patients with normal karyotype and are associated with DNMT3a mutations and …
Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute myeloid leukemia
Y Shi, Y Xue, C Wang, L Yu - Hematology, 2022 - Taylor & Francis
ABSTRACT Nucleophosmin 1 (NPM1, also known as B23) is a multifunctional protein
involved in a variety of cellular processes, including ribosomal maturation, centrosome …
involved in a variety of cellular processes, including ribosomal maturation, centrosome …