Mitotic cell division is tightly monitored by checkpoints that safeguard the genome from
instability. Failures in accurate chromosome segregation during mitosis can cause …

Metastatic melanoma is among the most enigmatic advanced cancers to clinically manage
despite immense progress in the way of available therapeutic options and historic …

Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase
(MAPK) pathway. In BRAF-driven melanoma cells treated with BRAF inhibitors …

Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to
cancer pathogenesis that is identified in most cancer types and is associated with poor …

Glioblastoma (GBM) progression is influenced by intratumoral heterogeneity. Emerging
evidence has emphasized the pivotal role of extrachromosomal circular DNA (eccDNA) in …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

In cancer, oncogenes can untether themselves from chromosomes onto circular,
extrachromosomal DNA (ecDNA) particles. ecDNA are common in many of the most …

Aneuploidy is defined as the cellular state of having a number of chromosomes that deviates
from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy …

Background BRAF-mutant melanoma patients benefit from the combinatorial treatments with
BRAF and MEK inhibitors. However, acquired drug resistance strongly limits the efficacy of …

Mitotic errors generate micronuclei entrapping mis-segregated chromosomes, which are
susceptible to catastrophic fragmentation through chromothripsis. The reassembly of …