Traumatic brain injury: mechanisms of glial response

RG Mira, M Lira, W Cerpa - Frontiers in physiology, 2021 - frontiersin.org
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …

Impact of intracellular innate immune receptors on immunometabolism

WC Chou, E Rampanelli, X Li, JPY Ting - Cellular & molecular …, 2022 - nature.com
Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis,
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …

Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): relevant signaling pathways and therapeutic strategies

J Jin, J Duan, L Du, W Xing, X Peng… - Frontiers in …, 2022 - frontiersin.org
Intracranial aneurysm subarachnoid hemorrhage (SAH) is a cerebrovascular disorder
associated with high overall mortality. Currently, the underlying mechanisms of pathological …

NLR-dependent regulation of inflammation in multiple sclerosis

M Gharagozloo, KV Gris, T Mahvelati… - Frontiers in …, 2018 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …

NLRX1 is a multifaceted and enigmatic regulator of immune system function

MA Nagai-Singer, HA Morrison, IC Allen - Frontiers in Immunology, 2019 - frontiersin.org
Over the last decade, significant progress has been achieved in defining mechanisms
underlying NLR regulation of immune system function. However, several NLR family …

[HTML][HTML] Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to …

B He, W Chen, J Zeng, W Tong, P Zheng - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
The study aims to investigate the effects of long noncoding RNA (lncRNA) transmitted
nuclear factor-κB interacting lncRNA (NKILA)-containing astrocyte-derived small …

NLR in eXile: Emerging roles of NLRX1 in immunity and human disease

RJ Pickering, LM Booty - Immunology, 2021 - Wiley Online Library
NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …

[HTML][HTML] Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in inflammatory bowel disease

HA Morrison, B Trusiano, AJ Rowe, IC Allen - biomedical journal, 2023 - Elsevier
A subset of Nucleotide-binding and leucine-rich repeat-containing receptors (NLRs) function
to mitigate overzealous pro-inflammatory signaling produced by NF-κB activation. Under …

Transcutaneous auricular vagus nerve stimulation promotes white matter repair and improves dysphagia symptoms in cerebral ischemia model rats

L Long, Q Zang, G Jia, M Fan, L Zhang, Y Qi… - Frontiers in Behavioral …, 2022 - frontiersin.org
Background Clinical and animal studies have shown that transcutaneous auricular vagus
nerve stimulation (ta-VNS) exerts neuroprotection following cerebral ischemia. Studies have …

The NLRP3 inflammasome: a new player in neurological diseases

E Eren, N Özören - Turkish Journal of Biology, 2019 - journals.tubitak.gov.tr
Inflammasomes are supramolecular protein complexes implicated in the detection of
pathogens or danger-associated molecules and are responsible for mounting the first line of …