Rapid advances are being made in the engineering of replication-competent viruses to treat
cancer. Adenovirus is a mildly pathogenic human virus that propagates prolifically in …

Gene therapy for the treatment of cancer was initiated with high levels of optimism and
enthusiasm. Recently, this perception has had to be tempered by the realisation that …

It has become apparent that the clinical success anticipated in the field of gene therapy has
been limited by progress in several of the fundamental areas of genetics, molecular and …

One of the biggest challenges facing cancer therapy is to generate tumour-specific treatment
strategies. Gene therapy hopes to achieve this by directing the activity of therapeutic genes …

Cancer-specificity is the key requirement for a drug or treatment regimen to be effective
against malignant disease—and has rarely been achieved adequately to date. Therefore …

Adeno-associated virus (AAV) type 2 vectors transfer stable, long-term gene expression to
diverse cell types in vivo. Many gene therapy applications require the control of long-term …

Malignant melanoma is characterized by growing incidence, early metastasis, and a lack of
effective treatment for advanced disease, suggesting a pressing need for novel therapeutic …

Oncolytic adenoviruses with restricted replication can be produced if the expression of
crucial transcription units of the virus is controlled by tissue-or tumor-specific promoters …

Gene therapy is an exciting novel approach for treating cancers resistant to currently
available modalities. Treatment approaches are based on taking advantage of molecular …

Regulated gene delivery systems are usually made of two elements: an inducible promoter
and a transactivator. In order to optimize gene delivery and regulation, a single viral vector …