Multiple endocrine neoplasia type 1 (MEN1), a rare tumor syndrome that is inherited in an
autosomal dominant pattern, is continuing to raise great interest for endocrinology …

Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumor syndrome inherited in
an autosomal dominant manner and characterized by a predisposition to a multitude of …

Pituitary adenomas are usually benign monoclonal tumours presenting either due to
hypersecretion of pituitary hormones, and/or due to local space occupying effects and …

The protein menin is encoded by the MEN1 gene, which is mutated in patients with multiple
endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a tumor suppressor …

Accumulating evidence suggests that epigenetic alterations play an important role in
chemically-induced carcinogenesis. Although the epigenome and genome may be equally …

Pancreatic neuroendocrine tumors (pNETs) are a rare group of cancers accounting for about
1–2% of all pancreatic neoplasms. About 10% of pNETs arise within endocrine tumor …

The identification of the multiple endocrine neoplasia type 1 (MEN1) gene in 1997 has
shown that germline heterozygous mutations in the MEN1 gene located on chromosome …

Non-coding RNAs (ncRNAs) have evolved in eukaryotes as epigenetic regulators of gene
expression. The most abundant regulatory ncRNAs are the 20–24 nt small microRNAs …

Despite its identification in 1997, the functions of the MEN1 gene—the main gene underlying
multiple endocrine neoplasia type 1 syndrome—are not yet fully understood. In addition …

MicroRNAs (miRNAs) are a class of small RNA molecules that regulate gene expression by
inhibiting the protein translation or targeting the mRNA cleavage. They play many important …