Neurological and immunological signals constitute an extensive regulatory network in our
body that maintains physiology and homeostasis. The cholinergic system plays a significant …

Parkinson's disease (PD) is the second most common age-associated neurodegenerative
disorder and is characterised by progressive loss of dopamine neurons in the substantia …

Endocrine disruptors (EDs) are chemical substances capable of affecting endocrine system
functioning and interfering with organ morphogenesis and physiological functions. The …

Excessive deposition of fibrillar collagen in the interstitial extracellular matrix (ECM) of
human lung tissue causes fibrosis, which can ultimately lead to organ failure. Despite our …

Hypothalamus is central to food intake and satiety. Recent data unveiled the expression of N-
methyl-D-aspartate receptors (NMDAR) on hypothalamic neurons and their interaction with …

Neddylation is a process similar to ubiquitination, and is critical in various inflammatory
diseases; however, its importance in the pathogenesis of inflammatory arthritis is not well …

The COVID-19 pandemic has prompted the exploration of effective treatment options, with
dexamethasone emerging as a key corticosteroid for severe cases. This review evaluates …

A hyperimmune state secondary to dysregulation of the immune system during lower
pulmonary viral infections, sepsis and in some cases non-infectious disorders, is now …

CDK6 is a pivotal kinase in cell cycle progression and has been targeted in many cancers
and degenerative diseases. Fisetin, a potent flavonol inhibitor of CDK6, was modified in …

Natural killer (NK) cells are essential players of the innate immune response that secrete
cytolytic factors and cytokines such as IFN-γ when contacting virus-infected or tumor cells …