Gut barrier structure, mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection

C Tincati, DC Douek, G Marchetti - AIDS research and therapy, 2016 - Springer
Over the past 10 years, extensive work has been carried out in the field of microbial
translocation in HIV infection, ranging from studies on its clinical significance to …

[HTML][HTML] Focus: Infectious diseases: Mechanisms of virologic control and clinical characteristics of HIV+ elite/viremic controllers

E Gonzalo-Gil, U Ikediobi, RE Sutton - The Yale journal of biology …, 2017 - ncbi.nlm.nih.gov
Human immunodeficiency virus type 1 (HIV-1) disease is pandemic, with approximately 36
million infected individuals world-wide. For the vast majority of these individuals, untreated …

HIV persists in CCR6+ CD4+ T cells from colon and blood during antiretroviral therapy

A Gosselin, TRW Salinas, D Planas, VS Wacleche… - Aids, 2017 - journals.lww.com
Objectives: The objective of this article is to investigate the contribution of colon and blood
CD4+ T-cell subsets expressing the chemokine receptor CCR6 to HIV persistence during …

Probiotic supplementation promotes a reduction in T‐cell activation, an increase in Th17 frequencies, and a recovery of intestinal epithelium integrity and …

G d'Ettorre, G Rossi, C Scagnolari… - Immunity …, 2017 - Wiley Online Library
Introduction HIV infection is characterized by a persistent immune activation associated to a
compromised gut barrier immunity and alterations in the profile of the fecal flora linked with …

[HTML][HTML] Combination anti–PD-1 and antiretroviral therapy provides therapeutic benefit against SIV

GH Mylvaganam, LS Chea, GK Tharp, S Hicks, V Velu… - JCI insight, 2018 - ncbi.nlm.nih.gov
Therapeutic strategies that augment antiviral immunity and reduce the viral reservoir are
critical to achieving durable remission of HIV. The coinhibitory receptor programmed death-1 …

IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques

J Harper, N Huot, L Micci, G Tharp, C King… - Nature …, 2021 - nature.com
Unlike HIV infection, which progresses to AIDS absent suppressive anti-retroviral therapy,
nonpathogenic infections in natural hosts, such African green monkeys, are characterized by …

Identification of novel HIV-1 dependency factors in primary CCR4+CCR6+Th17 cells via a genome-wide transcriptional approach

A Cleret-Buhot, Y Zhang, D Planas, JP Goulet… - Retrovirology, 2015 - Springer
Background The HIV-1 infection is characterized by profound CD4+ T cell destruction and a
marked Th17 dysfunction at the mucosal level. Viral suppressive antiretroviral therapy …

The prevention of 2, 4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in BALB/c mice by Jawoongo

JM Ku, SH Hong, SR Kim, HS Choi, HI Kim… - … and alternative medicine, 2018 - Springer
Background Jawoongo is an herbal mixture used in traditional medicine to treat skin
diseases. This study aimed to investigate whether Jawoongo ameliorates Atopic dermatitis …

Modeling the mechanisms by which HIV-associated immunosuppression influences HPV persistence at the oral mucosa

M Verma, S Erwin, V Abedi, R Hontecillas, S Hoops… - PloS one, 2017 - journals.plos.org
Human immunodeficiency virus (HIV)-infected patients are at an increased risk of co-
infection with human papilloma virus (HPV), and subsequent malignancies such as oral …

Preservation of gastrointestinal mucosal barrier function and microbiome in patients with controlled HIV infection

G Mak, JJ Zaunders, M Bailey, N Seddiki… - Frontiers in …, 2021 - frontiersin.org
Background Despite successful ART in people living with HIV infection (PLHIV) they
experience increased morbidity and mortality compared with HIV-negative controls. A …