Enhanced solubility and bioavailability of simvastatin by mechanochemically obtained complexes

R Kong, X Zhu, ES Meteleva, YS Chistyachenko… - International journal of …, 2017 - Elsevier
In the present work, complexes of simvastatin (SIM) with polysaccharide arabinogalactan
(AG) or disodium salt of glycyrrhizin acid (Na 2 GA) have been prepared using …

Preparation of solid dispersions of simvastatin and soluplus using a single-step organic solvent-free supercritical fluid process for the drug solubility and dissolution …

U Nandi, AL Ajiboye, P Patel, D Douroumis, V Trivedi - Pharmaceuticals, 2021 - mdpi.com
The study was designed to investigate the feasibility of supercritical carbon dioxide (scCO2)
processing for the preparation of simvastatin (SIM) solid dispersions (SDs) in …

[PDF][PDF] Recent strategies for improving solubility and oral bioavailability of piperine

H Salsabila, L Fitriani, E Zaini - Int. J. Appl. Pharm, 2021 - researchgate.net
L.), has long been used in Ayurveda and traditional Chinese medicine (TCM). This
compound has remarkable potential pharmacological properties, including being anti …

[HTML][HTML] Enhancing the bioavailability of clozapine through microwave-assisted formulation of a stable β-cyclodextrin inclusion complex

HP Patel, PJ Patel, BV Desai, RV Patel… - Colloids and Surfaces A …, 2024 - Elsevier
The low oral bioavailability of clozapine due to its poor aqueous solubility, poor dissolution
rate, and extensive hepatic first-pass metabolism poses a challenge to the effective …

Physicochemical and in vitro biological evaluations of furazolidone-based β-cyclodextrin complexes in Leishmania amazonensis

SG Carvalho, LA Siqueira, MS Zanini… - Research in veterinary …, 2018 - Elsevier
Recently, there have been numerous cases of leishmaniasis reported in different Brazilian
states. The use of furazolidone (FZD) to treat leishmaniasis has been previously described; …

Physicochemical characteristics of the complexes of simvastatin and atorvastatin calcium with hydroxypropyl-β-cyclodextrin produced by mechanochemical activation

R Kong, X Zhu, ES Meteleva, AV Dushkin… - Journal of Drug Delivery …, 2018 - Elsevier
In the present work, inclusion complexes of simvastatin (SIM), atorvastatin calcium (ATV)
with hydroxypropyl-β-cyclodextrin (HP-β-CD) have been prepared using mechanochemistry …

Co-milling of β-cyclodextrin with simvastatin: Solid state studies and dissolution profile

SS Braga, F El-Saleh, C Oliveira, JS Barbosa… - Journal of Drug Delivery …, 2023 - Elsevier
Simvastatin is a cholesterol-regulating drug of widespread use in the prevention of
cardiovascular diseases associated with dyslipidaemia. Herein we report on the preparation …

[PDF][PDF] Preparation and characterization of binary mixture of efavirenz and nicotinamide

E Zaini, F Rachmaini, F Armin, L Fitriani - Orient J Chem, 2015 - pdfs.semanticscholar.org
The purpose of this study was to prepare and characterize the binary mixture of efavirenz
and nicotinamide. The binary mixture of efavirenz and nicotinamide (in equimolar ratio) was …

Multicomponent Crystals of Piperine-Nicotinic Acid: The Physicochemical and Dissolution Rate Properties.

MD Octavia, H Hasmiwati, G Revilla… - Tropical Journal of …, 2023 - search.ebscohost.com
Piperine is included in Class II of the Biopharmaceutical Classification System. Piperine has
low solubility in water, resulting in low bioavailability. To improve the physicochemical …

ISOLASI PIPERIN DARI LADA HITAM (Piper nigrum L.) DAN UJI KEMURNIANNYA

MD Octavia, E Zaini, H Hasmiwati… - Jurnal Farmasi …, 2024 - jurnalfarmasihigea.org
Piperin merupakan senyawa alkaloid yang terdapat di dalam lada hitam (Piper nigrum L).
Pipierin diisolasi dari lada hitam dengan menggunakan metode sokletasi. Penelitian ini …