Gene therapy by expression constructs or down-regulation of certain genes has shown great
potential for the treatment of various diseases. The wide clinical application of nucleic acid …

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and one of the
leading causes of cancer-related death worldwide. Advanced HCC displays strong …

Abnormal tumour vasculature has a significant impact on tumour progression and response
to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis …

While immunotherapy holds great promise for combating cancer, the limited efficacy due to
an immunosuppressive tumor microenvironment and systemic toxicity hinder the broader …

Simple Summary Primary liver cancer, also known as Hepatocellular carcinoma (HCC), is
considered to be a major global health challenge. Due to delays in diagnosis at early …

Gene therapy provides a promising strategy for curing monogenetic disorders and complex
diseases. However, there are challenges associated with the use of viral delivery vectors …

The morbidity and mortality of hepatic fibrosis caused by various etiologies are high
worldwide, and the trend is increasing annually. At present, there is no effective method to …

Hepatocellular carcinoma (HCC) is a fatal disease with limited therapeutic choices. The
stroma-rich tumor microenvironment hinders the in vivo delivery of most nanomedicines …

While immunotherapy has emerged as a promising strategy to treat glioblastoma multiforme
(GBM), the limited availability of immunotherapeutic agents in tumors due to the presence of …

Background Kinase inhibitor sorafenib is the most widely used drug for advanced HCC
clinical treatment nowadays. However, sorafenib administration is only effective for a small …