[HTML][HTML] RNA-binding proteins in tumor progression

H Qin, H Ni, Y Liu, Y Yuan, T Xi, X Li… - Journal of hematology & …, 2020 - Springer
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

[HTML][HTML] Long noncoding RNAs in cancer pathways

AM Schmitt, HY Chang - Cancer cell, 2016 - cell.com
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …

RNA-binding proteins in cancer: old players and new actors

B Pereira, M Billaud, R Almeida - Trends in cancer, 2017 - cell.com
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …

Potential of long non‐coding RNAs in cancer patients: from biomarkers to therapeutic targets

S Chandra Gupta… - International journal of …, 2017 - Wiley Online Library
Because of high specificity and easy detection in the tissues, serum, plasma, urine and
saliva, interest in exploring the potential of long non‐coding RNAs (lncRNAs) in cancer …

Long noncoding RNA and cancer: a new paradigm

A Bhan, M Soleimani, SS Mandal - Cancer research, 2017 - AACR
In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

Y Zhang, Q He, Z Hu, Y Feng, L Fan, Z Tang… - Nature structural & …, 2016 - nature.com
Long noncoding RNAs (lncRNAs) play critical roles during tumorigenesis by functioning as
scaffolds that regulate protein-protein, protein-DNA or protein-RNA interactions. Using a …

PI3K/AKT/mTOR pathway-related long non-coding RNAs: roles and mechanisms in hepatocellular carcinoma

Y Wu, Y Zhang, X Qin, H Geng, D Zuo, Q Zhao - Pharmacological research, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide with high
prevalence and lethality. The oncogenic phosphoinositide 3-kinase/protein kinase …

[HTML][HTML] Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression

Y Jiang, YY Jiang, JJ Xie, A Mayakonda… - Nature …, 2018 - nature.com
Squamous cell carcinomas (SCCs) are aggressive malignancies. Previous report
demonstrated that master transcription factors (TFs) TP63 and SOX2 exhibited overlapping …

RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer

W Li, X Deng, J Chen - Seminars in cancer biology, 2022 - Elsevier
ABSTRACT RNA-binding proteins (RBPs) are key players in cellular physiology through
posttranscriptional regulation of the expression of target RNA transcripts. By modulating the …

[HTML][HTML] Oncogenic role of THOR, a conserved cancer/testis long non-coding RNA

Y Hosono, YS Niknafs, JR Prensner, MK Iyer… - Cell, 2017 - cell.com
Large-scale transcriptome sequencing efforts have vastly expanded the catalog of long non-
coding RNAs (lncRNAs) with varying evolutionary conservation, lineage expression, and …