Nanopore-based sensors have established themselves as a prominent tool for solution-
based, single-molecule analysis of the key building blocks of life, including nucleic acids …

Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …

Single-molecule counting is the most accurate and precise method for determining the
concentration of a biomarker in solution and is leading to the emergence of digital diagnostic …

The chemical nature and precise position of posttranslational modifications (PTMs) in
proteins or peptides are crucial for various severe diseases, such as cancer. State-of-the-art …

Nanopore systems have emerged as a leading platform for the analysis of biomolecular
complexes with single-molecule resolution. The conformation of biomolecules, such as …

Nanopore sensing technology, as an emerging analytical method, has the advantages of
simple operation, fast output, and label-free and has been widely used in fields such as …

Nanopore technology holds great promise for a wide range of applications such as
biomedical sensing, chemical detection, desalination, and energy conversion. For sensing …

Since their introduction in 2001, solid-state nanopores have been increasingly exploited for
the detection and characterization of biomolecules ranging from single DNA strands to …

Sequence identification of peptides and proteins is central to proteomics. Protein
sequencing is mainly conducted by insensitive mass spectroscopy because proteins cannot …

Transcription, a critical process in molecular biology, has found many applications in RNA
synthesis, including mRNA vaccines and RNA therapeutics. However, current RNA …