Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management

J He, D Liu, L Zhao, D Zhou… - Experimental and …, 2022 - spandidos-publications.com
Myocardial infarction is one of the primary causes of mortality in patients with coronary heart
disease worldwide. Early treatment of acute myocardial infarction restores blood supply of …

Mitochondria-associated endoplasmic reticulum membranes in cardiovascular diseases

P Gao, Z Yan, Z Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …

Novel insight into the role of endoplasmic reticulum stress in the pathogenesis of myocardial ischemia‐reperfusion injury

H Zhu, H Zhou - Oxidative Medicine and Cellular Longevity, 2021 - Wiley Online Library
Impaired function of the endoplasmic reticulum (ER) is followed by evolutionarily conserved
cell stress responses, which are employed by cells, including cardiomyocytes, to maintain …

Roles and therapeutic implications of endoplasmic reticulum stress and oxidative stress in cardiovascular diseases

Y Zhou, DD Murugan, H Khan, Y Huang, WS Cheang - Antioxidants, 2021 - mdpi.com
In different pathological states that cause endoplasmic reticulum (ER) calcium depletion,
altered glycosylation, nutrient deprivation, oxidative stress, DNA damage or energy …

The role of autophagy in cardiovascular disease: Cross-interference of signaling pathways and underlying therapeutic targets

B Jiang, X Zhou, T Yang, L Wang, L Feng… - Frontiers in …, 2023 - frontiersin.org
Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic proteins
and organelles, which realizes the metabolic needs of cells and the renewal of organelles …

Diacerein attenuate LPS-induced acute lung injury via inhibiting ER stress and apoptosis: Impact on the crosstalk between SphK1/S1P, TLR4/NFκB/STAT3, and …

NS Youssef, AS Elzaitony, NAA Baky - Life Sciences, 2022 - Elsevier
Aims Acute lung injury (ALI) is a life-threatening clinical problem with high mortality rate and
limited treatments or preventive options that represents a major challenge for clinicians …

Endoplasmic reticulum stress serves an important role in cardiac ischemia/reperfusion injury

Y Ruan, J Zeng, Q Jin, M Chu… - Experimental and …, 2020 - spandidos-publications.com
Although acute myocardial infarction is one of the most common fatal diseases worldwide,
the understanding of its underlying pathogenesis continues to develop. Myocardial …

Protein translation: biological processes and therapeutic strategies for human diseases

X Jia, X He, C Huang, J Li, Z Dong, K Liu - Signal Transduction and …, 2024 - nature.com
Protein translation is a tightly regulated cellular process that is essential for gene expression
and protein synthesis. The deregulation of this process is increasingly recognized as a …

Sigma-1 receptor signaling: in search of new therapeutic alternatives for cardiovascular and renal diseases

FJ Munguia-Galaviz, AG Miranda-Diaz… - International journal of …, 2023 - mdpi.com
Cardiovascular and renal diseases are among the leading causes of death worldwide, and
regardless of current efforts, there is a demanding need for therapeutic alternatives to …

[HTML][HTML] Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role?

R Resende, T Fernandes, AC Pereira… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Mood disorders like major depression and bipolar disorder (BD) are among the most
prevalent forms of mental illness. Current knowledge of the neurobiology and …