Genomic profiling for clinical decision making in lymphoid neoplasms

L De Leval, AA Alizadeh, PL Bergsagel… - Blood, The Journal …, 2022 - ashpublications.org
With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

Molecular determinants of clinical outcomes in a real-world diffuse large B-cell lymphoma population

W Alduaij, B Collinge, S Ben-Neriah… - Blood, The Journal …, 2023 - ashpublications.org
Molecular heterogeneity of diffuse large B-cell lymphoma (DLBCL) underlies the variable
outcomes achieved with immunochemotherapy. However, outcomes of gene expression …

Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age

B Burkhardt, U Michgehl, J Rohde, T Erdmann… - Nature …, 2022 - nature.com
While survival has improved for Burkitt lymphoma patients, potential differences in outcome
between pediatric and adult patients remain unclear. In both age groups, survival remains …

Epstein–Barr virus‐associated lymphomas decoded

K Bednarska, R Chowdhury, JWD Tobin… - British Journal of …, 2024 - Wiley Online Library
Summary Epstein–Barr virus (EBV)‐associated lymphomas cover a range of histological B‐
and T‐cell non‐Hodgkin and Hodgkin lymphoma subtypes. The role of EBV on B‐cell …

The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphoma

M Lacroix, H Beauchemin, C Khandanpour… - Frontiers in …, 2023 - frontiersin.org
DDX3X is an RNA helicase with many functions in RNA metabolism such as mRNA
translation, alternative pre-mRNA splicing and mRNA stability, but also plays a role as a …

Saturation genome editing of DDX3X clarifies pathogenicity of germline and somatic variation

EJ Radford, HK Tan, MHL Andersson… - Nature …, 2023 - nature.com
Loss-of-function of DDX3X is a leading cause of neurodevelopmental disorders (NDD) in
females. DDX3X is also a somatically mutated cancer driver gene proposed to have tumour …

Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns

K Dreval, LK Hilton, M Cruz, H Shaalan, S Ben-Neriah… - Blood, 2023 - ashpublications.org
Follicular lymphoma (FL) accounts for∼ 20% of all new lymphoma cases. Increases in
cytological grade are a feature of the clinical progression of this malignancy, and eventual …

Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas

J Choi, M Ceribelli, JD Phelan, B Häupl, GW Wright… - Cancer cell, 2024 - cell.com
Glucocorticoids have been used for decades to treat lymphomas without an established
mechanism of action. Using functional genomic, proteomic, and chemical screens, we …

Single-cell transcriptomics of pediatric Burkitt lymphoma reveals intra-tumor heterogeneity and markers of therapy resistance

C Corinaldesi, AB Holmes, G Martire, A Tosato… - Leukemia, 2024 - nature.com
Burkitt lymphoma (BL) is the most frequent B-cell lymphoma in pediatric patients. While most
patients are cured, a fraction of them are resistant to therapy. To investigate BL …

Incidence of Burkitt lymphoma in the United States during 2000 to 2019

W Mburu, SS Devesa, D Check… - … journal of cancer, 2023 - Wiley Online Library
Burkitt lymphoma (BL) is an aggressive B‐cell lymphoma that occurs worldwide. A study of
BL in the US National Cancer Institute's Surveillance, Epidemiology and End Results …