The multifaceted role of reactive oxygen species in tumorigenesis

A Kirtonia, G Sethi, M Garg - Cellular and Molecular Life Sciences, 2020 - Springer
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Mitogen‐activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways?

Y Son, YK Cheong, NH Kim, HT Chung… - Journal of signal …, 2011 - Wiley Online Library
Mitogen‐activated protein kinases (MAPKs) are serine‐threonine protein kinases that play
the major role in signal transduction from the cell surface to the nucleus. MAPKs, which …

Cellular response to oxidative stress: signaling for suicide and survival

JL Martindale, NJ Holbrook - Journal of cellular physiology, 2002 - Wiley Online Library
Reactive oxygen species (ROS), whether produced endogenously as a consequence of
normal cell functions or derived from external sources, pose a constant threat to cells living …

Reactive oxygen species in the activation of MAP kinases

Y Son, S Kim, HT Chung, HO Pae - Methods in enzymology, 2013 - Elsevier
There are three well-defined subgroups of mitogen-activated protein kinases (MAPKs): the
extracellular signal-regulated kinases (ERKs), the c-Jun N-terminal kinases (JNKs), and the …

The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor

GS Tjabringa, J Aarbiou, DK Ninaber… - The Journal of …, 2003 - journals.aai.org
Antimicrobial peptides produced by epithelial cells and neutrophils represent essential
elements of innate immunity, and include the defensin and cathelicidin family of …

Mitogen-activated protein kinase activation in UV-induced signal transduction

AM Bode, Z Dong - Science's STKE, 2003 - science.org
Experimental evidence supported by epidemiological findings suggests that solar ultraviolet
(UV) irradiation is the most important environmental carcinogen leading to the development …

Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation

G Loo - The Journal of nutritional biochemistry, 2003 - Elsevier
Phytochemicals are potential cancer chemopreventive agents, based partly on cellular
research establishing that phytochemicals inhibit the proliferation of cancer cells. To …

The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal

HJ Forman, JM Fukuto, T Miller, H Zhang… - Archives of biochemistry …, 2008 - Elsevier
During the past several years, major advances have been made in understanding how
reactive oxygen species (ROS) and nitrogen species (RNS) participate in signal …

[HTML][HTML] The redox biology network in cancer pathophysiology and therapeutics

G Manda, G Isvoranu, MV Comanescu, A Manea… - Redox biology, 2015 - Elsevier
The review pinpoints operational concepts related to the redox biology network applied to
the pathophysiology and therapeutics of solid tumors. A sophisticated network of intrinsic …

Loss of Hepatocyte Growth Factor/c-Met Signaling Pathway Accelerates Early Stages of N-nitrosodiethylamine–Induced Hepatocarcinogenesis

T Takami, P Kaposi-Novak, K Uchida… - Cancer research, 2007 - AACR
Hepatocyte growth factor (HGF) has been reported to have both positive and negative
effects on carcinogenesis. Here, we show that the loss of c-Met signaling in hepatocytes …