Heterogeneity and endotypes in type 1 diabetes mellitus

MJ Redondo, NG Morgan - Nature Reviews Endocrinology, 2023 - nature.com
Despite major advances over the past decade, prevention and treatment of type 1 diabetes
mellitus (T1DM) remain suboptimal, with large and unexplained variations in individual …

Machine learning in precision diabetes care and cardiovascular risk prediction

EK Oikonomou, R Khera - Cardiovascular Diabetology, 2023 - Springer
Artificial intelligence and machine learning are driving a paradigm shift in medicine,
promising data-driven, personalized solutions for managing diabetes and the excess …

[HTML][HTML] Stress-induced β cell early senescence confers protection against type 1 diabetes

H Lee, GS Sahin, CW Chen, S Sonthalia, SM Cañas… - Cell Metabolism, 2023 - cell.com
During the progression of type 1 diabetes (T1D), β cells are exposed to significant stress
and, therefore, require adaptive responses to survive. The adaptive mechanisms that can …

Phenotypic and genetic classification of diabetes

AJ Deutsch, E Ahlqvist, MS Udler - Diabetologia, 2022 - Springer
The historical subclassification of diabetes into predominantly types 1 and 2 is well
appreciated to inadequately capture the heterogeneity seen in patient presentations …

Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas

K Hrovatin, A Bastidas-Ponce, M Bakhti, L Zappia… - Nature …, 2023 - nature.com
Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

[HTML][HTML] University students' participation in outdoor recreation and the perceived well-being effects of nature

R Puhakka - Journal of outdoor recreation and tourism, 2021 - Elsevier
It is increasingly recognized that interacting with nature promotes well-being and health for
both adults and children. Less is known about the role of nature in people's everyday lives …

Fat distribution patterns and future type 2 diabetes

H Yamazaki, S Tauchi, J Machann, T Haueise… - Diabetes, 2022 - Am Diabetes Assoc
Fat accumulation in the liver, pancreas, skeletal muscle, and visceral bed relates to type 2
diabetes (T2D). However, the distribution of fat among these compartments is heterogenous …

[PDF][PDF] A certified de-identification system for all clinical text documents for information extraction at scale

L Radhakrishnan, G Schenk, K Muenzen… - JAMIA …, 2023 - academic.oup.com
Objectives Clinical notes are a veritable treasure trove of information on a patient's disease
progression, medical history, and treatment plans, yet are locked in secured databases …

Stratification of diabetes in the context of comorbidities, using representation learning and topological data analysis

M Wamil, A Hassaine, S Rao, Y Li, M Mamouei… - Scientific Reports, 2023 - nature.com
Diabetes is a heterogenous, multimorbid disorder with a large variation in manifestations,
trajectories, and outcomes. The aim of this study is to validate a novel machine learning …

Mitochondrial Dysfunction, Oxidative Stress, and Inter-Organ Miscommunications in T2D Progression

R Veluthakal, D Esparza, JM Hoolachan… - International Journal of …, 2024 - mdpi.com
Type 2 diabetes (T2D) is a heterogenous disease, and conventionally, peripheral insulin
resistance (IR) was thought to precede islet β-cell dysfunction, promoting progression from …