Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Acute neurological conditions such as cerebrovascular diseases and trauma are associated
with irreversible loss of neurons and glial cells. Severe or prolonged injury results in …

Members of the caspase family of cysteine proteases play central roles in coordinating the
stereotypical events that occur during apoptosis. Because the major executioner caspases …

Neonatal hypoxic/ischemic (H/I) brain injury causes neurological impairment, including
cognitive and motor dysfunction as well as seizures. However, the molecular mechanisms …

Apoptosis is coordinated by members of the caspase family of aspartic acid-specific
proteases. Other members of this protease family also play essential roles in inflammation …

Synapse loss occurs normally during development and pathologically during
neurodegenerative disease. Long-term depression, a proposed physiological correlate of …

The aspartate-specific cysteine protease caspase-1 is activated by the inflammasomes and
is responsible for the proteolytic maturation of the cytokines IL-1β and IL-18 during infection …

BACKGROUND: The number of mouse mutants and strains with neural tube closure defects
(NTDs) now exceeds 190, including 155 involving known genes, 33 with unidentified genes …

The caspase family of cysteine proteases represents the executioners of programmed cell
death (PCD) type I or apoptosis. For years, caspases have been known for their critical roles …

• Cell death is important in medicine• Why do we not have a medicine based on apoptosis?•
The machinery of cell death• Cells have many options other than apoptosis• The response of …