Exploring the expanding universe of small RNAs

J Shi, T Zhou, Q Chen - Nature cell biology, 2022 - nature.com
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering
RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs …

Noncanonical roles of tRNAs: tRNA fragments and beyond

Z Su, B Wilson, P Kumar, A Dutta - Annual review of genetics, 2020 - annualreviews.org
As one of the most abundant and conserved RNA species, transfer RNAs (tRNAs) are well
known for their role in reading the codons on messenger RNAs and translating them into …

Action mechanisms and research methods of tRNA-derived small RNAs

Y Xie, L Yao, X Yu, Y Ruan, Z Li, J Guo - Signal Transduction and …, 2020 - nature.com
Abstract tRNA-derived small RNAs (tsRNAs), including tRNA-derived fragments (tRFs) and
tRNA halves (tiRNAs), are small regulatory RNAs processed from mature tRNAs or …

Emerging roles of tRNA-derived fragments in cancer

M Fu, J Gu, M Wang, J Zhang, Y Chen, P Jiang, T Zhu… - Molecular cancer, 2023 - Springer
Abstract tRNA-derived fragments (tRFs) are an emerging category of small non-coding
RNAs that are generated from cleavage of mature tRNAs or tRNA precursors. The advance …

Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosis

L Zhu, J Li, Y Gong, Q Wu, S Tan, D Sun, X Xu, Y Zuo… - Molecular cancer, 2019 - Springer
Abstract tRNA-derived small RNA (tsRNA) is a novel regulatory small non-coding RNA and
participates in diverse physiological and pathological processes. However, the presence of …

tRNA-derived RNA fragments in cancer: current status and future perspectives

M Yu, B Lu, J Zhang, J Ding, P Liu, Y Lu - Journal of Hematology & …, 2020 - Springer
Non-coding RNAs (ncRNAs) have been the focus of many studies over the last few decades,
and their fundamental roles in human diseases have been well established. Transfer RNAs …

tRNA-derived fragments and tRNA halves: the new players in cancers

L Zhu, J Ge, T Li, Y Shen, J Guo - Cancer Letters, 2019 - Elsevier
Abstract tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are small non-coding
RNAs derived from precursor tRNAs or mature tRNAs. Depending on the sources, tRFs can …

Deciphering the tRNA-derived small RNAs: origin, development, and future

B Liu, J Cao, X Wang, C Guo, Y Liu, T Wang - Cell Death & Disease, 2021 - nature.com
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding
RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the …

Non-coding RNAs as mediators of epigenetic changes in malignancies

S Kumar, EA Gonzalez, P Rameshwar, JP Etchegaray - Cancers, 2020 - mdpi.com
Simple Summary This review discusses the role of non-coding RNAs (ncRNAs) in cancer
epigenetics, mostly focusing on how deregulated microRNAs (miRNAs) and long non …

Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3–mediated gene silencing

Z Su, C Kuscu, A Malik, E Shibata, A Dutta - Journal of Biological Chemistry, 2019 - ASBMB
tRNA fragments (tRFs) and tRNA halves have been implicated in various cellular processes,
including gene silencing, translation, stress granule assembly, cell differentiation …