Antiviral Activity of N1,N3-Disubstituted Uracil Derivatives against SARS-CoV-2 Variants of Concern

AE Siniavin, MS Novikov, VA Gushchin… - International Journal of …, 2022 - mdpi.com
Despite the widespread use of the COVID-19 vaccines, the search for effective antiviral
drugs for the treatment of patients infected with SARS-CoV-2 is still relevant. Genetic …

Synthesis and biological evaluation of novel salicylidene uracils: Cytotoxic activity on human cancer cell lines and inhibitory action on enzymatic activity

AH Poslu, ŞE Aslan, G Koz, E Senturk… - Archiv der …, 2024 - Wiley Online Library
A series of salicylidene uracil (1–18) derived from 5‐aminouracil and substituted
salicylaldehydes were analyzed for cytotoxic activity and enzyme inhibitory potency. Nine …

Uracil: A Pharmacophore with Diverse Biological Potential

K Jain, S Sharma, D Utreja - ChemistrySelect, 2024 - Wiley Online Library
This review article delves into the intricate biological activities of uracil, an essential
pyrimidine Base pivotal in RNA structures. Examining its involvement in nucleic acid …

[HTML][HTML] Synthesis and antiviral properties of 1-Substituted 3-[ω-(4-Oxoquinazolin-4 (3H)-yl) alkyl] uracil Derivatives

S Robert, A Graciela - Acta Naturae (англоязычная версия), 2020 - cyberleninka.ru
А series of uracil derivatives containing a 4-oxoquinazoline fragment bound to the nitrogen
atom N3 of the pyrimidine ring by a short methylene bridge was synthesized to search for …

Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication

MP Paramonova, AA Ozerov, MS Novikov… - Mendeleev …, 2019 - elibrary.ru
A series of 1-[(bromophenoxy) alkyl] uracil–coumarin conjugates has been obtained through
the preparation of starting 1-[(bromophenoxy) alkyl] uracil derivatives, followed by their …

Novel 1-[5-(4-bromophenoxy) pentyl]-3-(2-arylamino-2-oxoethyl) uracils and their antiviral properties

MP Paramonova, AL Khandazhinskaya… - Mendeleev …, 2017 - pmc.ncbi.nlm.nih.gov
The title compounds were prepared from 1-[5-(4-bromophenoxy) pentyl] uracil by the
introduction of N-arylacetamide moiety at the 3-position, the better approach involving the …

Synthesis of 1-[ω-(Bromophenoxy) alkyl]-3-Naphthalenylmethyl Uracil Derivatives and Their Analogues as Probable Inhibitors of Human Cytomegalovirus Replication

MP Paramonova, ES Gureeva, AA Ozerov… - Doklady Biochemistry …, 2022 - Springer
A new series of 1-[ω-(bromophenoxy) alkyl]-uracil derivatives containing naphthalen-1-yl,
naphthalen-2-yl, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene-9-ylmethyl …

Enantioselective synthesis of 5-methylidenedihydrouracils as potential anticancer agents

M Pięta, J Kędzia, D Kowalczyk, J Wojciechowski… - Tetrahedron, 2019 - Elsevier
An efficient, versatile, enantioselective synthesis of 1, 3-disubstituted and 1, 3, 6-
trisubstituted 5-methylidenedihydrouracils applying Horner-Wadsworth Emmons …

New N1-(4-aryloxybenzyl) uracils containing N3-positioned 4-(trimethyleneoxy) benzoic acid moiety, and study of their antiviral activity against SARS-CoV-2 and …

MS Novikov, MP Paramonova, IM Kirillov… - Mendeleev …, 2023 - Elsevier
Abstract New title uracil derivatives, 4-{3-[2, 6-dioxo-3-(4-aryl-oxybenzyl)-3, 6-
dihydropyrimidin-1 (2H)-yl] propoxy} benzoic acids and their butoxy homologues, were …

Synthesis of 1-[ω-(Bromophenoxy) alkyl]-3-naphthalenylmethyl Derivatives of Uracil and Their Analogues As Probable Inhibitors of Human Cytomegalovirus …

MP Paramonova, ES Gureeva, AA Ozerov… - Doklady Biochemistry …, 2023 - Springer
The synthesis of a new series of 1-[ω-(bromophenoxy) alkyl]-uracil derivatives containing in
position 3 naphthalen-1-yl-, naphthalen-2-yl-, 1-bromonaphthalen-2-ylmethyl, benzyl, and …