Introduction Immunotherapies for multiple sclerosis (MS) significantly decrease the risk of
new relapses. However, the chronic compartmentalized inflammation and …

Macrophages play an essential role in rheumatoid arthritis. Depending on their phenotype
(M1 or M2), they can play a role in the initiation or resolution of inflammation. The M1/M2 …

Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative
processes that damage the central nervous system (CNS). However, it is not well …

Obesity is a main global health issue and an outstanding cause of morbidity and mortality
predisposing to type 2 diabetes (T2DM) and cardiovascular diseases. Huge research efforts …

Dysregulation of signaling pathways in multiple sclerosis (MS) can be analyzed by
phosphoproteomics in peripheral blood mononuclear cells (PBMCs). We performed in vitro …

Fingolimod (FTY720) is a new generation oral treatment for multiple sclerosis (MS). So far,
FTY720 was mainly considered to target trafficking of immune cells but not brain cells such …

Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales,
from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype …

Acute spinal cord injury (SCI) is a devastating condition with many consequences and no
known effective treatment. Although it is quite easy to diagnose traumatic SCI, the …

Shifting paradigms in multiple sclerosis: from disease-speci... : Current Opinion in Neurology
Shifting paradigms in multiple sclerosis: from disease-specific, through population-specific toward …

Slow-burning inflammation at the lesion rim is connected to the expansion of chronic
multiple sclerosis (MS) lesions. However, the underlying processes causing expansion are …