Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors
characterized by a high frequency of hereditary forms. Based on transcriptome classification …

Abstract Acquired resistance to 5-fluorouracil (5-FU) is a major barrier to benefit from
chemotherapy in colon cancer patients. Hydrogen sulfide (H 2 S), mainly produced by …

Research on rare tumors heavily relies on suitable models for basic and translational
research. Paragangliomas (PPGL) are rare neuroendocrine tumors (NET), developing from …

Metastasis is the leading cause of cancer-related death. However, it remains a poorly
understood aspect of cancer biology, and most preclinical cancer studies do not examine …

Several lines of evidence, including the recent discovery of novel susceptibility genes, point
out an important role for the mammalian target of rapamycin (mTOR) signaling pathway in …

Preclinical studies show that stroma affects sensitivity of prostate cancer cells via activation
of the CXCR4/CXCL12 pathway. Here we studied the effect of CXCR4 inhibition combined …

Metastatic pheochromocytoma represents one of the major clinical challenges in the field of
neuroendocrine oncology. Recent molecular characterization of pheochromocytoma …

Paragangliomas and pheochromocytomas are rare neuroendocrine tumors characterized by
a large spectrum of hereditary predisposition. Based on gene expression profiling …

Pheochromocytomas/paragangliomas (PPGLs) are rare neuroendocrine tumours linked to
more than 15 susceptibility genes. PPGLs present with very different genotype/phenotype …

As a result of intense genetic studies of families with specific mutations, the road to better
therapeutic intervention for pheochromocytoma (PHEOs) and parangangliomas (PGLs) has …