In eukaryotic cells, gene transcription is regulated by sequence-specific DNA-binding
transcription factors that recognize promoter and enhancer elements near the transcriptional …

Until recently our approach to analyzing human genetic diseases has been to accurately
phenotype patients and sequence the genes known to be associated with those …

The structural basis for binding of the acidic transcription activator Gcn4 and one activator-
binding domain of the Mediator subunit Gal11/Med15 was examined by NMR. Gal11 …

The endothelium regulates vascular homeostasis, and endothelial dysfunction is a
proximate event in the pathogenesis of atherothrombosis. Stimulation of the endothelium …

Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in
many species. Recent studies have shown that KLFs play a fundamental role in regulating …

The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms
to tightly couple fuel supply with energy demand across a wide range of physiologic and …

KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly
conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and …

Forkhead box class O 3a (FOXO3a) is a transcription factor and tumor suppressor linked to
longevity that determines cell fate through activating transcription of cell differentiation …

KLF1 (formerly known as EKLF) regulates the development of erythroid cells from bi-potent
progenitor cells via the transcriptional activation of a diverse set of genes. Mice lacking Klf1 …

Nucleotide excision repair is initiated by two different damage recognition subpathways,
global genome repair (GGR) and transcription-coupled repair (TCR). In GGR, XPC detects …