Protective effect of misoprostol against paclitaxel-induced cardiac damage in rats

İ Aktaş, FM Gur, S Bilgiç - Prostaglandins & Other Lipid Mediators, 2024 - Elsevier
Objective One of the most critical reasons for limiting cancer treatment is the toxic effects of
anti-cancer drugs on healthy tissues and organs. This study aims to investigate the possible …

Silymarin, an antioxidant flavonoid, protects the liver from the toxicity of the anticancer drug paclitaxel

FM Gür, S Bilgiç - Tissue and Cell, 2023 - Elsevier
One of the biggest factors that negatively affect the cancer treatment plan is the toxic effects
of chemotherapeutics on non-target cells and tissues. This information prompted us to …

Misoprostol alleviates paclitaxel-induced liver damage through its antioxidant and anti-apoptotic effects

FM Gür, İ Aktaş, S Bilgiç, M Pekince - Molecular & Cellular Toxicology, 2022 - Springer
Backgrounds Anticancer drugs may damage non-target cells and tissues. One of the biggest
reasons for changing or stopping chemotherapy regimens is these adverse effects …

Protective potential of misoprostol against kidney alteration via alleviating oxidative stress in rat following exposure to paclitaxel

İ Aktaş, A Yahyazadeh - Tissue and Cell, 2022 - Elsevier
The present study investigated the protective effect of misoprostol (MSP)(0.2 mg/kg, oral)
against kidney injury caused by paclitaxel (PLX)(2 mg/kg, intraperitoneal) in female Sprague …

[PDF][PDF] Propolis protective effects against doxorubicin-induced multi-organ toxicity via suppression of oxidative stress, inflammation, apoptosis, and histopathological …

EK Mohamed, AA Osman, AM Moghazy… - … Res. Appl. Chem, 2021 - researchgate.net
Doxorubicin (DOX) is effective chemotherapy in several malignancies, but large-scale
toxicities limit its clinical usefulness. Propolis has been reported to exhibit a broad spectrum …

Improvement in heat stress-induced multiple organ dysfunction and intestinal damage through protection of intestinal goblet cells from prostaglandin E1 analogue …

HP Hii, WZ Lo, YH Fu, MH Chen, CC Shih, CM Tsao… - Life Sciences, 2022 - Elsevier
Aims Heat stroke is a life-threatening disorder triggered by thermoregulatory failure.
Hyperthermia-induced splanchnic hypoperfusion has been reported to induce intestinal …

[PDF][PDF] Silymarin protects kidneys from paclitaxel-induced nephrotoxicity.

FM Gür, İ Aktaş - 2022 - researchgate.net
The effects of drugs used in cancer treatment are not only specific to cancer cells but also
negatively affect healthy cells. This study, it was aimed to investigate the protective effects of …

A synthetic prostaglandin E1 analogue, misoprostol, ameliorates paclitaxel-induced oxidative damage in rat brain

FM Gür, S Bilgiç - Prostaglandins & other lipid mediators, 2022 - Elsevier
The main objective of our study was to examine the protection of misoprostol (MP) on
paclitaxel (PAX) side effects in rat brains. Twenty-eight female Sprague-Dawley rats were …

Biochemical and Histopathological Investigation of the Protective Effect of Lutein in Rat Kidney Exposed to Cisplatin

S Bilgiç, FM Gür, İ Aktaş - Medical Records, 2022 - dergipark.org.tr
Aim: The aim of this study was to determine the protection of lutein (L)(100 mg/kg, orally)
against kidney damage caused by cisplatin (Cis)(10mg/kg, intraperitoneal). Materials and …

Protective effects of silymarin against paclitaxel-induced cardiac toxicity

İ Aktaş, FM Gur, JL Martínez, S Bilgiç… - … y del Caribe de …, 2024 - blacpma.ms-editions.cl
En este estudio, se investigó la protección de la silimarina (SY) contra los efectos nocivos
del paclitaxel (PX) en el corazón. Se administraron 2 mg/kg de PX por vía intraperitoneal al …