Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic
complications create a substantial burden on both the afflicted patients and society as a …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

Chronic pain is associated with neuronal plasticity. Here we use resting-state functional
magnetic resonance imaging to investigate functional changes in patients suffering from …

Chronic pain conditions are associated with abnormalities in brain structure and function.
Moreover, some studies indicate that brain activity related to the subjective perception of …

It is well-recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

Recent neuroimaging studies suggest that the brain adapts with pain, as well as imparts risk
for developing chronic pain. Within this context, we revisit the concepts for nociception, acute …

Functional connectivity (FC), or the statistical interdependence of blood-oxygen dependent
level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool …

During resting conditions the brain remains functionally and metabolically active. One
manifestation of this activity that has become an important research tool is spontaneous …

Brain function has traditionally been studied in terms of physiological responses to
environmental demands. This approach, however, ignores the fact that much of the brain's …

Objective Fibromyalgia (FM) is considered to be the prototypical central chronic pain
syndrome and is associated with widespread pain that fluctuates spontaneously. Multiple …