Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and
contribute to neurodegenerative pathology. Although microglia have been the focus of work …

Abstract The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying
the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

BACKGROUND: Studies suggest that inflammation is involved in the neurodegenerative
cascade leading to Alzheimer's disease (AD) pathology and symptoms. This study sought to …

Higher levels of proinflammatory cytokines are found in Parkinson's disease (PD) patient's
brains and inflammation is thought to be a major contributor to the neurodegeneration …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

The cholinergic hypothesis of decline in dementia, whereby deficits in learning, memory and
behavior are caused, at least in part, by decreased levels of acetylcholine (ACh) in the brain …

Abstract Aims Cholinesterase inhibitors (ChEIs) are used for symptomatic treatment of
Alzheimer's disease. These drugs have vagotonic and anti-inflammatory properties that …

Alzheimer's disease (AD) is a neurodegenerative disease leading to a progressive and
irreversible loss of mental functions. It is characterized by 3 stages according to the evolution …

Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly. Deposition of
amyloid β plaque and associated neuroinflammation are the major hallmarks of AD …

Increasing evidence supports a propensity towards inflammation in Alzheimer's disease
(AD) pathogenesis. In our previous studies we observed high levels of IL-16, IL-18 and TGF …