Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining
telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

The majority of common variants associated with common diseases, as well as an unknown
proportion of causal mutations for rare diseases, fall in noncoding regions of the genome …

The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a
RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of …

Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their
telomere length via expression of an enzymatic complex called telomerase. Similarly, more …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Background. Promoter mutation in the human telomerase reverse transcriptase gene
(hTERT) occurs in~ 75% of primary glioblastoma (GBM). Although the mutation appears to …

Background There are controversial results concerning the prognostic implication of TERT
promoter mutation in glioma patients concerning MGMT status. In this meta-analysis, we …

The TERT promoter (pTERT) mutations, C228T and C250T, play a significant role in
malignant transformation by telomerase activation, oncogenesis and immortalisation of cells …

TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and
have emerged to play critical roles in tumor progression. The mutations upregulate TERT …