In eukaryotic cells, ATP generation is generally viewed as the primary function of
mitochondria under normoxic conditions. Reactive oxygen species (ROS), in contrast, are …

Mitochondria are essential cellular organelles that are involved in regulating cellular energy,
metabolism, survival, and proliferation. To some extent, cancer is a genetic and metabolic …

Mitochondria are highly dynamic organelles which can change their shape, via processes
termed fission and fusion, in order to adapt to different environmental and developmental …

Epithelial ovarian cancer (EOC) is a gynecologic malignancy with a poor prognosis due to
resistance to first-line chemotherapeutic agents. Some cancer cells are primarily dependent …

Regardless of the recent advances in therapeutic developments, cancer is still among the
primary causes of death globally, indicating the need for alternative therapeutic strategies …

Endothelial progenitor cells (EPCs) are reduced in number and impaired in function in
diabetic patients. Whether and how Nrf2 regulates the function of diabetic EPCs remains …

Glioblastoma (GBM), the most aggressive brain tumor, is associated with a median survival
at diagnosis of 16–20 months and limited treatment options. The key hallmark of GBM is …

Background The development of castration-resistant prostate cancer (CRPC) remains a
major obstacle in the treatment of prostate cancer (PCa). Dysregulated mitochondrial …

The crosstalk between tumor cells and the adjacent normal epithelium contributes to cancer
progression, but its regulators have remained elusive. Here, we show that breast cancer …

Prostate cancer (PCa) affects millions of men worldwide and is a major cause of cancer-
related mortality. Race-associated PCa health disparities are also common and are of both …