The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) constitutes a rare and aggressive
malignancy originating from plasmacytoid dendritic cells (pDCs) with a primarily cutaneous …

Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …

Lymphoid neoplasms represent a heterogeneous group of disease entities and subtypes
with markedly different molecular and clinical features. Beyond genetic alterations, lymphoid …

Aberrant DNA methylation constitutes a key feature of pediatric acute lymphoblastic
leukemia at diagnosis, however its role as a predisposing or early contributor to leukemia …

Purpose: Medullary thyroid carcinoma (MTC) presents a distinct biological context from other
thyroid cancers due to its specific cellular origin. This heterogeneous and rare tumor has a …

Glucocorticoid (GC) resistance in childhood relapsed B-cell acute lymphoblastic leukemia (B-
ALL) represents an important challenge. Despite decades of clinical use, the mechanisms …

Genomic analyses have redefined the molecular subgrouping of pediatric acute
lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted …

DNA methylation is a key epigenetic modification to regulate gene expression in mammalian
cells. Abnormal DNA methylation in gene promoters is common across human cancer types …