Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …

Microglia are crucial for maintaining brain health and neuron function. Here, we report that
microglia establish connections with neurons using tunneling nanotubes (TNTs) in both …

This review article provides an overview of the different species that α‐synuclein aggregates
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …

Synucleinopathies, such as Parkinson's disease (PD), multiple system atrophy (MSA), and
dementia with Lewy bodies (DLB), are defined by the presence of α-synuclein (αSYN) …

Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the
emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has …

α-Synuclein (α-Syn) aggregation into fibrils with prion-like features is intimately associated
with Lewy pathology and various synucleinopathies. Emerging studies suggest that α-Syn …

Progressive aggregation of the protein alpha-synuclein (α-syn) and loss of dopaminergic
neurons in the substantia nigra pars compacta (SNpc) are key histopathological hallmarks of …

Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

Abstract α-Synuclein is critical in the pathogenesis of Parkinson's disease and related
disorders, yet it remains unclear how its aggregation causes degeneration of human …