The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …

Toll-like receptor (TLR) activation induces inflammatory responses in macrophages by
activating temporally defined transcriptional cascades. Whether concurrent changes in the …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Intercellular transfer of microRNAs can mediate communication between critical effector
cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial …

The excessive production of reactive oxygen species (ROS), associated with inflammation,
leads to a condition of oxidative stress. Oxidative stress is a major contributing factor to the …

This review focuses on the role of oxidative processes in atherosclerosis and the
cardiovascular diseases (CVD) that can arise as a result. Atherosclerosis represents a state …

Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …

The present study investigates the modulating effects of nicotinamide on the cytokine
response to endotoxin. In an in vitro model of endotoxaemia, human whole blood was …

Falciparum malaria is a complex disease with no simple explanation, affecting organs where
the parasite is rare as well as those organs where it is more common. We continue to argue …