The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …

The number of available breast cancer cell (BCC) lines is small, and only a very few of them
have been extensively studied. Whether they are representative of the tumours from which …

Background The prevalence and spectrum of predisposing mutations among children and
adolescents with cancer are largely unknown. Knowledge of such mutations may improve …

Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …

Characteristic patterns of gene expression measured by DNA microarrays have been used
to classify tumors into clinically relevant subgroups. In this study, we have refined the …

A basal epithelial phenotype is found in not more than 15% of all invasive breast cancers.
Microarray studies have shown that this phenotype is associated with breast cancers that …

PURPOSE: The morphologic and molecular phenotype of breast cancers may help identify
patients who are likely to carry germline mutations in BRCA1 and BRCA2. This study …

ContextAmong cancer-free women aged 35 years or older, tamoxifen reduced the incidence
of estrogen receptor (ER)–positive but not ER-negative breast cancer. The effect of …

Genetic and lifestyle/environmental factors are implicated in the aetiology of breast cancer.
This review summarizes the current state of knowledge on rare high penetrance mutations …

Breast and ovarian cancers are among the most common cancers in women. It is known that
a woman is at higher risk for breast or ovarian cancer if a family member has had the …